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软组织黏液纤维肉瘤31例报道 被引量:3

Soft tissue myxofibrosarcoma: a report of 31 cases
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摘要 目的本研究旨在探讨软组织黏液纤维肉瘤的临床、影像、病理特点及治疗预后。方法回顾性分析我科2007年8月至2017年4月期间收治的软组织黏液纤维肉瘤31例。分析其临床、影像、病理特点及治疗预后。结果男14例,女17例,中位年龄:59岁(21~80岁)。发生在上肢10例,下肢20例,躯干1例,深筋膜深层19例,深筋膜浅层12例;20例行单纯手术,6例(手术+术后放疗),4例(手术+术后化疗),1例(手术+术后放疗+术后化疗),外科边界广泛25例,边缘6例,保肢26例,截肢5例,根据FNCLCC病理分级,低度恶性为13例,中度恶性8例,高度恶性为10例。随访6~97个月,局部复发2例,占6.5%,转移3例占9.7%,Kaplan分析5年生存率为93.2%,肺转移与患者生存率相关(P<0.05)。结论软组织黏液纤维肉瘤以外科手术治疗为主,肿瘤学预后较好,肺转移是影响患者生存的最主要因素。 Objective To detect the clinical,radiological,pathological features and prognosis of soft tissue myxofibrosarcoma.Methods We retrospectively reviewed 31 cases of soft tissue myxofibrosarcoma treated in our department between Aug.2007 and Apr.2017.We analyzed the clinical,radiological,pathological features and prognosis.Results This study included 14 males and 17 females.The median age was 59 years old(range:21-80 years).The tumor located at the upper limb in 10 cases,at the lower limb 20 cases and at the trunk 1 case.The tumor located beneath the deep fascia in 19 cases and superficially in 12 cases.Twenty cases underwent surgery alone;6 cases underwent surgery and postoperative radiotherapy;4 cases underwent surgery and postoperative chemotherapy;1 case underwent surgery,postoperative chemotherapy and radiotherapy.Wide surgical margin was achieved in25 cases,while 6 cases marginal margin.Limb salvage surgery was performed in 26 cases and amputation in 5 cases.According to FNCLCC system,13 cases were of low grade,8 cases intermediate grade and 10 cases high grade.All the patients were followed up 6-97 months.Local recurrence occurred in 2 cases(6.5%),and distal metastasis occurred in 3 cases(9.7%).The 5-years survival rate was 93.2%in a Kaplan-Meier analysis.Lung metastasis decreased the survival rate significantly(P<0.05).Conclusions Surgery is the main method to treat soft tissue myxofibrosarcoma.Oncological results are acceptable when treated appropriately.Lung metastasis is a key factor affecting the survival rate.
作者 邓志平 田萌萌 苏永彬 刘巍峰 徐海荣 丁宜 牛晓辉 DENG Zhi-ping;TIAN Meng-meng;SU Yong-bin;LIU Wei-feng;XU Hai-rong;DING Yi;NIU Xiao-hui(Department of Orthopedic Oncology,Beijing Jishuitan Hospital,Beijing,100035,China)
出处 《中国骨与关节杂志》 CAS 2019年第5期328-331,共4页 Chinese Journal of Bone and Joint
关键词 纤维肉瘤 软组织肿瘤 外科手术 Fibrosarcoma Soft tissue neoplasms Surgical procedures,operative
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