摘要
目的 探讨肿瘤坏死因子α(TNFα)、内皮素 (ET)及一氧化氮 (NO)在妊娠高血压综合征(简称妊高征 )发病机制中的意义。方法 17例正常孕妇和 4 1例妊高征孕妇在产前产后分别测定血TNFα、ET及NO水平 ;用电镜观察胎盘和脐血管内皮细胞超微结构。结果 ①妊高征患者产前血TNFα和ET水平均明显升高 ,NO水平下降 ,随病情加重而更明显 ;产后 72hTNFα和ET水平下降 ,NO水平增高。②妊高征患者胎盘和脐血管内皮细胞均有损伤性表现 ,且与产前血TNFα变化相一致。结论 妊高征患者胎盘和脐血管内皮细胞的损伤和功能性变化与血TNFα水平增高有关 ,TNFα可能作为血管内皮损伤的一种免疫因子引发妊高征。
ObjectiveTo explore significance associated relation between the content of tumor necrosis factor(TNF), endothelin(ET), nitric oxide(NO) and endothelial cell structure of placenta and cord vessels with pregnancy induced hypertension (PIH). MethodsSeventeen normal-term pregnant women (the control group) and 41 pregnant women with PIH were enrolled in the study. The concentrations of TNF, ET and NO in plasma were measured both before and after delivery. The endothelial cell structure of placenta and umbilical cord blood vessels were studied with electron microscope. Results①The TNF, ET levels in plasma of the patients with PIH were generally higher than that in the controls before delivery, especially in the moderate and severe PIH cases. The NO level was lower than that in the controls before delivery. ②The damage of endothelial cells of placenta and umbilical cord blood vessels was observed. This damage related to the level of plasma TNF and ET. ConclusionsOur study demonstrated an increase of TNF and ET level in patients with PIH. The results may show an abnormal maternal immune reaction to the fetus, and the damage of endothelial cell would then be caused. Therefore, an abnormal higher TNF level may have an effect on the pathogenesis of PIH.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2002年第6期369-371,共3页
Chinese Journal of Nuclear Medicine
