摘要
目的:探讨 Bcl- 2蛋白及 Ras癌基因蛋白在新疆不同民族喉鳞癌中的表达情况。方法 :采用免疫组化链酶素生物素技术 (L SAB法 )对 83例喉鳞癌病变组织中 Bcl- 2和 Ras基因蛋白进行了检测。结果:83例喉鳞癌病变组织中 Bcl- 2的表达率为 3 0 .1% ;其表达与临床分期无关。Ras蛋白的表达率为 40 .9% ,其表达与临床分期有关。民汉间 Bcl- 2的表达无统计学意义 (P >0 .0 5 )。而民汉间 Ras蛋白的表达有统计学意义 (P <0 .0 5 )。民、汉间 Bcl-2基因无显著性差异 ,而 Ras癌基因有显著性差异。结论:Bcl- 2基因和
Objective: To investigate the expression of Bcl 2 oncoprotein and Ras oncoprotein in laryngeal squamous cell carcinoma (LSCC)of different ethnic patients. Methods: 83 LSCC were studied with immunohistochemical LSAB (labeled streptavidin biotin) method. Results: The results indicated that 30.1% cases of LSCC were Bcl 2 positive, and 40.9% cases of LSCC were Ras positive. The positive rate of Bcl 2 oncoprotein was not connected with clinical stage, and Ras oncoprotein was connected with it. No significant statistical differences at Bcl 2 between the Han and the minority nations, and has statistical significant differences at Ras. Conclusion: This study suggests that Bcl 2 and Ras oncoprotein may play an important role in the development of LSCC.
出处
《新疆医科大学学报》
CAS
2002年第4期397-398,401,共3页
Journal of Xinjiang Medical University
