摘要
感染性疾病是由病原体入侵人体所引起的各种疾病,严重威胁人类健康及社会稳定。抗感染药物是治疗感染性疾病的基本手段。近年来,病原体对抗感染药物的耐药性逐渐增强,现代医学在感染性疾病治疗中遭遇瓶颈。间充质干细胞是来源于中胚层的多能干细胞,在感染性疾病治疗中展现巨大潜力,机制与间充质干细胞多向分化潜能、免疫调节功能及分泌抗菌物质密切相关。间充质干细胞可以分泌抗菌物质抑制病原体生长繁殖,分化为不同类型细胞进行组织修复,其免疫调节功能既可以促进免疫反应清除病原体,也可以抑制炎症风暴减轻组织损伤。间充质干细胞应用前景广阔,但仍面临诸多挑战。如缺乏临床应用规范,输入体内后归巢率及存活率低,可引发免疫排斥反应及肿瘤形成等。深入开展间充质干细胞治疗感染性疾病的基础与临床研究,阐明其治疗机制并精准利用其治疗优势,通过基因编辑等技术提高间充质干细胞治疗的安全性及有效性,开发出更高效的间充质干细胞治疗方案,为感染性疾病患者带来新的希望。
Infectious diseases refer to all diseases caused by pathogens that invade the body,which seriously threaten human health and social stability.Anti-infective drugs are essential for the treatment of infectious diseases.In recent years,the resistance of pathogens to anti-infective drugs has gradually increased,and modern medicine has encountered a bottleneck in the treatment of infectious diseases.Mesenchymal stem cells(MSCs),which are pluripotent stem cells of mesodermal origin,have shown great potential in the treatment of infectious diseases,and the mechanisms are closely related to the multidirectional differentiation potential,immunomodulatory function and secretion of antimicrobial substances.MSCs can secrete antimicrobial substances to inhibit the growth and reproduction of pathogens,also can differentiate into different types of cells for tissue repairing.Their immunomodulatory function can not only promote the immune response to clear pathogens,but also inhibit inflammatory storms to reduce the damage to the tissue.The application of MSCs is promising,but there are still many challenges.For example,no clinical application specification,low homing rate and survival rate after injection into the body,may trigger immune rejection and tumor formation.To carry out in-depth basic and clinical research on MSC therapy for infectious diseases,to elucidate its therapeutic mechanism and precisely utilize its therapeutic advantages,to improve the safety and efficacy of MSC therapy through gene editing and other technologies,and to develop more efficient MSC therapeutic protocols,so as to bring a new hope to patients with infectious diseases.
作者
杜莉莉
孙韬
张铠遵
刘映辰
陈泊宇
韩璐遥
吕金珠
DU Li-li;SUN Tao;ZHANG Kai-zun;LIU Ying-chen;CHEN Bo-yu;HAN Lu-yao;LYU Jin-zhu(Department of Pathophysiology,School of Basic Medical Sciences,China Medical University,Shenyang 110122;School of Basic Medical Sciences,China Medical University,Shenyang 110122;The First Hospital Affiliated to the First Clinical College,China Medical University,Shenyang 110122;Shengjing Hospital Affiliated to the Second Clinical College,China Medical University,Shenyang 110122)
出处
《微生物学杂志》
北大核心
2025年第1期124-131,共8页
Journal of Microbiology
基金
辽宁省应用基础研究计划项目(2023JH2/101300020)
辽宁省教育厅高校基本科研项目(3110024077)
中国医科大学大学生创新创业训练计划资助项目。
关键词
间充质干细胞
病原体
感染性疾病
免疫调节
损伤修复
旁分泌
mesenchymal stem cells
pathogen
infectious diseases
immune regulation
injury repair
paracrine
