摘要
目的:通过心理干预前后免疫参数的变化,了解心理干预能否提高癌症患者的免疫功能。方法:运用病例对照实验设计,采用多因素综合分析统计方法,对120例(采集到血样者81例)患者进行比较研究。结果:化疗期间经心理干预后,患者的各项免疫参数均有不同程度的提高;NK细胞活性对心理行为的变化比较敏感,干预后明显提高;实验组免疫球蛋白三项指标化疗前后比较稳定,但对照组化疗后明显下降。癌症患者的愤怒表达和掩饰性性格特点与NK细胞活性显著相关;影响免疫功能的因素随免疫参数的不同而异;各种影响因素以综合作用为主,部分因素间交互作用明显。结论:心理干预对提高癌症患者的免疫功能起到一定作用,但其机制和稳定性有待进一步研究。
Objective:To examine the effects of the psychological intervention on immune function in breast and lung cancer patients during the chemotherapy.Methods:120(81out of them got the blood sample)inpatients were randomly assigned to either intervention group or con-trol group.Psychological and immune parameter variables in both groups were measured two times(before and after chemotherapy).Results:Immune parameters were increased in different levels and NK(natural killer)cell activity were more sensitive to psychological intervention and changed significantly after intervention compared with before intervention in patients who were intervention group.Serum immunoglobulins were stable during chemotherapy in intervention group,but de-creased much after chemotherapy in control group.The factors influencing immune function were different among immune parameter and the influential way of factors was synthetic.Conclusion:These data suggest that there were some effects of psychological intervention on immune function in cancer patients,but its mechanism and stability need to be tested further.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第12期841-844,共4页
Chinese Journal of Clinical Oncology
基金
中国科学院知识创新工程KSCX2-03
国家自然科学基金资助(编号:39830130)
关键词
心理干预
癌症
免疫功能
Cancer patients Psychological intervention Immune parameters
