摘要
用克山病病区粮喂饲大鼠15周,其肝脏、心脏、胰腺、肾脏、脾脏及全血Se GSH-Px活性都明显低于非病区粮喂养的大鼠,骨骼肌Se GSH-Px活性亦有降低的趋势,但差异不显著。Vit.E测定的结果表明,用病区粮喂养的大鼠肝脏和血清中Vit.E的含量明显高于用非病区粮喂养的大鼠;肾脏、脾脏和胰腺中Vit.E的含量和非病区粮组大鼠相比,亦有增高的趋势,但没有统计学差异;唯独在心肌和骨骼肌中Vit.E的含量两组间基本相同,病区粮组无丝毫增多迹象。 病区粮喂养大鼠肝脏和血清中Vit.E含量明显增多是吸收增多的表现,是对体内低硒的代偿反应,说明病区粮喂养大鼠体内对Vit.E的需要量增加。Vit.E在体内变化不一致,说明各脏器对Vit.E的摄取能力存在着差异,由于心肌和骨骼肌摄入Vit.E的能力较弱,尤易发生Vit.E相对不足的现象,成为克山病病变之主要靶器官。因此应重视硒和Vit.E联合缺乏在克山病发病中的作用。
After rats had kept on a diet containing grains cultivated in the endemic areas of Keshan disease (KD) for 15 weeks, activities of Se GSH-Px in their liver, myocardium, kidney, spleen and whole blood were significantly lower than those kept on a diet containing grains cultivated in the non-KD area. However, vitamin E contents in the liver and serum of the rats kept on a diet of the KD-area grains were significantly higher than those kept on a diet of the non-KD-area grains. The vitamin contents in the kidney, spleen and pancreas of the ratskept on a diet of the KD-area grains tended to decrease, but not to a statistically sgnificant extent. The vitamin contents of the myocardium and skeletal muscle in the rats kept on a diet of the KD-area grains were no change, compared with those kept on a diet of the non-KD area grains.
The rise in vitamin E contents in the liver and serum of rats kept on a diet of the KD-area grains suggested an increased uptake of vitamin E to compensate for the detrimental effects of decreased Se GSH-Px activities. It was also suggested that vitamin E requirement was increased in the rats kept on a diet of the KD-area grains. There were a various changes in vitamin E contents in organs of the rats kept on a diet of the KD-area grains, suggesting different uptake ability of the vitamin in organs. The poor ability of vitamin E uptake in the myocardium and skeletal muscle in the rats kept on a diet of the KD-area grains could make them be prone to relative deficiency of the vitamin, which, therefore, would make them become main target organs in KD. Thus, in addition to selenium deficiency, relative vitamin E deficiency should be paid attention to. That is, combined deficiency of vitamin E and selenium could be involed in the development of KD.
出处
《地方病通报》
1992年第2期14-18,共5页
Endemic Diseases Bulletin
关键词
克山病
维生素E
硒
Keshan disease
Vitamin E
SeGSH-Px
