摘要
目的 探讨HER3和HER4 (Humanepidermal growth factorreceptor 3and 4 )过度表达与肺癌临床病理的关系 ,明确erbB3和erbB4癌基因在肺癌生长中的作用。 方法 用免疫组化法分别检测 2 0例非癌肺石蜡组织及 70例肺癌 (43例鳞癌和 2 7例腺癌 )石蜡组织中HER3和HER4的表达 ,并采用肺癌组织染色减去癌旁上皮组织染色≥ 2 +的标准 ,对它们在肺癌中是否呈过度表达进行判断。 结果 HER3和HER4在支气管粘膜细胞及肺泡细胞存在阳性表达 (+) ;HER4在正常支气管细胞和肺泡细胞表达率的差异有统计学意义 ;肺癌中存在HER4的过度表达 ,但无HER3的过度表达 ;肺癌中HER4的过度表达与肺癌病理类型、分化程度无相关性 ,而与肺癌淋巴结转移、TNM分期、患者术后生存率相关。 结论 erbB4是晚期肺癌生长的调控基因之一 ,人为地干预HER4的过度表达可能是一种治疗晚期肺癌的有效方法。
Objective To understand the function of erbB3 and erbB4 oncogenes in lung cancer. Methods Twenty cases of paraffin embedded tissues from non cancer lung and 70 cases of paraffin embedded tissues from lung cancer( 43 cases of squamous cell cancer and 27 cases of adenocarcinoma ) were tested for the expressions of HER3, HER4 by means of Immunohistochemical assay.Results HER3, HER4 were slightly expressed in bronchi and alveoli; the over expression of HER4 was found in lung cancer and correlates with the lymph node metastasis, TNM staging and survival after operation.Conclusion erbB4 is one of the genes to regulate the growth of lung cancer in advanced stages, and artificial interference to HER4 over expression may be a good way for the treatment of lung cancer in advanced stages. However, erbB3 has slight function parobably in the cell reproduction of lung cancer.
出处
《现代实用医学》
2003年第1期12-14,共3页
Modern Practical Medicine
