摘要
目的 研究苯妥英钠对烧伤患者血清免疫抑制因子的影响。 方法 应用酶联免疫吸附法 (ELISA)检测烧伤患者应用苯妥英钠后血清中肿瘤坏死因子 (TNF α)的含量 ,同时观察患者的血清对丝裂原植物血凝素 (PHA)诱导淋巴细胞增殖转化试验的影响。 结果 烧伤患者血清中有免疫抑制因子存在 ;应用苯妥英纳后 ,免疫抑制因子的含量降低 (P <0 0 1) ;血清淋巴细胞增殖活性显著高于未应用苯妥英纳组 (P <0 0 1)。 结论 苯妥英纳对烧伤患者免疫抑制因子有抑制作用。
Objective To investigate the affect of Dilantin on the immunosuppressive factor in serum of the burns patients. Methods Tumor necrosis factor α(TNF α) in serum was determined with ELISA method after administration of Dilandin and the effect of the serum from patients with Dilandin on lymphocyte proliferate conversion induced by PHA was observed. Results Immunosuppressive factors was found present in serum of the burn patients. The level of the immunosuppressive factor was reduced after the administration of Dilandin; the proliferation of lymphocyte was much significant with Dilandin than that without Dilandin ( P <0.01). Conclusions Dilantin could inhibit the serum immunosuppressive factor in burn patients.
出处
《华北国防医药》
2002年第5期313-315,共3页
Medical Journal of Beijing Military Region
