摘要
本文综述有关细胞因子和转录因子在调控巨核细胞和血小板生成的作用。巨核细胞的生成包括巨核系祖细胞增殖与分化为未成熟巨核细胞 ,再进一步分化为成熟巨核细胞并释出血小板的过程。在巨核系造血的早期阶段 ,主要由TPO及IL 1 ,IL 3和PDGF调控 ;在分化的后期有TPO及IL 6和IL 1 1参与。多个转录因子也参与巨核细胞的分化过程。GATA 1 ,FOG 1和Fli 1主要作为早期至中期巨核细胞生成的调节因子。NF E2则主要参与晚期巨核细胞分化和血小板生成的调控。目前对血小板释放的机制还缺乏深入了解。一氧化氮可能通过引起巨核细胞的凋亡 。
The role of cytokines and transcription factors on the regulation of megakaryocytopoiesis and platelet production are reviewed in this article. Megakaryocytopoiesis involves the proliferation and differentiation of megakaryocytic progenitor cells into immature megakaryocytes, and the differentiation of immature megakaryocytes to mature megakaryocytes which produce platelets. The former is regulated mainly by thrombopoietin (TPO) and to a lesser degree by other cytokines such as interleukin 1 (IL 1), IL 3 and platelet derived growth factor (PDGF), the later by TPO and probably IL 6 and IL 11. A number of transcription factors have been implicated in the control of megakaryocyte differentiation. GATA 1, FOG 1 and Fli 1 are essential regulators in early and mid stages of megakaryocytopoiesis. NF E2 regulates late stage of megakaryocytopoiesis and platelet production. However, the platelet release mechanism is poorly understood. Nitric oxide (NO) may act in the stage of platelet release through induction of apoptosis in megakaryocytes.
出处
《中国实验血液学杂志》
CAS
CSCD
2002年第6期580-585,共6页
Journal of Experimental Hematology
