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洛索洛芬钠治疗强直性脊柱炎的疗效与安全性评价 被引量:14

The efficacy and safety of loxoprofen sodium in the treatment of ankylosing spondylitis
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摘要 目的 :观察洛索洛芬钠 (乐松 )治疗强直性脊柱炎 (AS)的疗效与安全性。方法 :选择 5 2例活动性AS患者 ,口服洛索洛芬钠 ,6 0mg ,tid。分别在 0周和第 4周末进行疗效和安全性评价。结果 :可评价患者共 5 0例 ,2例脱落。经过 4周的治疗 ,乐松对AS患者的总有效率为 92 .4 2 % ,其中对各主要疗效指标均有明显改善 (P <0 .0 5 )。耐受性较好 ,不良反应发生率仅为 8% ,主要为轻中度的胃肠道不适 ,无严重或危及生命的不良反应发生。结论 :洛索洛芬钠通过其抗炎镇痛作用对活动性AS的疼痛与功能受限有较好的改善 ,安全性较好。 Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of ankylosing spondylitis (AS) patients.Methods:52 AS patients were enrolled in a random order,open trial.Each patient received loxoprofen sodium at a dosage of 60mg,tid,taking after meals.The efficacy and safety assessment were performed at 0 and 4 weeks after taking the medicine.Results:All data were available in 50 patients who completed the trial with 2 drop outs.After 4 weeks of treatment, 92.42% of the AS patients responded to loxoprofen sodium.Significant improvements were noticed in all 3 primary outcome measurements( P <0.05).Loxoprofen sodium were well tolerated in most patients.Only 8% of the patients had side effects, maily discomfort in stomach.There were no serious or life threatening side effects. Conclusion:Loxoprofen sodium is a reasonably strong non steroidal anti inflammatory drug for AS patients with good safety profile.
出处 《中国新药杂志》 CAS CSCD 北大核心 2002年第11期878-881,共4页 Chinese Journal of New Drugs
关键词 洛索洛芬钠 治疗 强直性脊柱炎 疗效 安全性 loxoprofen sodium ankylosing spondylitis efficacy safety
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参考文献7

  • 1李胜光,崔鸿雁,郭军华,杨春花,黄烽.洛索洛芬治疗膝骨关节炎的临床评价[J].中国新药杂志,2000,9(12):856-858. 被引量:15
  • 2赵伟,黄烽.强直性脊柱炎治疗新进展[J].中国新药杂志,2001,10(7):485-488. 被引量:19
  • 3Van der LS,Valkenburg H,Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria[J]. Arthritis Rheum, 1984,27: 361-368.
  • 4Anderson J, Baron G, van der Heijde D, et al. ASAS preliminary criteria for short term improvement in ankylosing spondylitis[J].Arthritis Rheum ,2001,44:1876-1886.
  • 5Calin A,Garrett S,Whitelock H, et al. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index(BASFI)[J].J Rheumatol, 1994,21:2281-2285.
  • 6Garrett S, J enkinson T, Whitelock H, et al. A new approach to defining disease status in AS:the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)[J].J Rheumatol, 1994,21: 2286-2291.
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二级参考文献1

  • 1黄烽 赵伟.反应停对强直性脊柱炎治疗作用的初步观察.首届华夏风湿性疾病诊断治疗学术会议论文汇编[M].上海:中华医学会风湿病学会,1999.123.

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