摘要
目的:观察中药降脂通脉方对冠心病心绞痛伴高脂血症患者血脂及血浆ET、CGRP、TXB2、PGF1α水平的影响。方法:选择冠心病心绞痛伴高脂血症住院患者50例,随机分为中药组28例、对照组22例。对照组按西药常规治疗,降脂用月见草油胶丸。中药组除不用月见草油胶丸外,余西药治疗同对照组,另外服用降脂通脉方。两组疗程均为4周。结果:中药组临床症状计分及ST段下移值均较对照组低(P<0.01)。中药组可显著降低TC、TG,升高HDL-C,且可显著降低ApoB、升高ApoA1;对照组亦可明显降低TC、TG,但对HDL-C、ApoA1、ApoB没有显著影响。中药组可显著降低血浆ET、TXB2水平(P<0.05),显著升高CGRP水平(P<0.05),并且明显降低TXB2/PG1α比值(P<0.01);对照组仅在降低ET、TXB2水平方面有显著性差异,对升高CGRP、PGF1α及对TXB2/PGF1α比值无明显影响。中药组在降低血浆ET、TXB2及升高CGRP和降低TXB2/PGF1α比值方面均明显优于对照组(P<0.05,P<0.01)。结论:降脂通脉方对冠心病心绞痛合并高脂血症患者具有良好的调脂、抗AS作用及血管内皮细胞保护作用,临床疗效显著。
Objective:To observe the influences of Jiangzhi Tongmai recipe in the patients with angina pectoris associated with hyperlipemia on blood lipid and ET, CGRP, TXB2, PGF1α levels in plasma. Methods:50 inpatients, with angina pectoris associated with hyperlipermia, were assigned randomly into two groups:control group (treated by routine western medicine and reduced lipid by Oenothera biennise oil capsule,n=22) and trial group (treated as same western medicine as control group except Oenothera biennise oil capsule replaced by Jiangzhi Tongmai recipe,n=28). They were treated for 4 weeks. Results:Clinical symptom scores and ST segment depression tites in trial group were lower significantly than those in control group (P<0.01). In trial group TG and ApoB were lower while HDL-C and ApoA1 were higher than those before treatment significantly;in control group TC and TG were lowed significantly while there were no significant influences on HDL-C, ApoA1 and ApoB. In trial group ET, TXB2 and TXB2/PGF1α ratio were lowed (P<0.05, P<0.01) and CGRP was increased significantly (P<0.05). In control group only ET and TXB2 were lowed significantly while there were no significant influences on CGRP,PGF1αand TXB2/PGF1α ratio. In trial group there were better actions on lowing ET,TXB2 and TXB2/PGF1αratio and increasing CGRP compared with control group. Conclusion:Jiangzhi Tongmai recipe had good actions on regulating lipid, inhibiting AS and protecting vessel endothelial cell in the patients with angina pectoris associated with hyperlipemia, showing good clinical effects.
出处
《中国中医药信息杂志》
CAS
CSCD
2002年第12期11-12,15,共3页
Chinese Journal of Information on Traditional Chinese Medicine
