摘要
目的 评价卵巢移行细胞癌 (TCC)的临床生物学行为、预后以及影响预后的因素。方法 回顾性分析北京协和医院妇产科 2 0年间收治的卵巢TCC 5 8例的临床资料 ,并进行统计学分析。结果 5 8例患者中 ,年龄中位数为 3 5～ 75岁 ,平均为 (5 5± 10 )岁。 40例为单侧 (69% ) ,CA12 5水平为 75～ 143 3U/L ,平均为 (687± 3 65 )U/L。 5 8例患者均在我院接受肿瘤细胞减灭术 ,40例 (69% )患者达到满意的肿瘤细胞减灭术效果 ,病理分级为G1、G2 、G3级者分别为 7% (4/ 5 8)、45 % (2 6/ 5 8)和 48%(2 8/ 5 8)。 5 8例中 ,2 3例 (40 % )有淋巴结转移 ;46例 (79% )手术病理分期为Ⅲ期和Ⅳ期。所有患者均接受了不同疗程的化学药物治疗 ,2 6例 (45 % )术后复发 ,3 1例 (5 3 % )死亡。对于可能影响预后的各因素进行分析发现 ,本病的预后与手术彻底性 (P <0 0 1)、术前CA12 5水平 (P <0 0 1)、双侧卵巢受累(P <0 0 5 )以及淋巴结转移 (P <0 0 5 )有良好的相关性。
Objective To evaluated clinico biologic behavior, prognosis and relative prognostic factors of transitional cell carcinoma of the ovary Methods The clinical records of 58 patients with transitional cell carcinoma of the ovary, who received treatment in the department of Obstetrics and Gynecology, Peking Union Medical College Hospital in 20 years, were reviewed retrospectively The data were analyzed statistically by SPSS 10 0 Results Among 58 cases, the median age was 55±10 (35-75) years old 31% of them had bilateral ovary involvement, and the median level of CA 125 was (687±365) U/L All patients received cytoreductive surgery in our hospital, 69% of them got optimal cytoreduction Pathologic results showed that G 1,G 2,G 3 were 7%, 45% and 48% respectively,40% were demonstrated lymphnode metastasis Nearly 80% of patients were classified to International Federation of Gynecology and Obstetrics (FIGO) stage Ⅲ and Ⅳ Different courses of chemotherapy were given to all patients The recurrence occurred in 45% of cases and the death rate was 53% The Cox hazards regression model was used to analyze the possible prognostic factors and revealed that tumor residuals( P <0 01), preoperative level of CA 125 ( P <0 01), bilateral ovary involvement ( P <0 05) and lymphnode metastasis ( P <0 05) were the most important prognostic factors Conclusions Transitional cell carcinoma of ovary is an uncommon type of ovarian cancer It usually behaves better prognosis when compared with papillary serous cystadenocarcinoma of the ovary
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2002年第12期733-735,共3页
Chinese Journal of Obstetrics and Gynecology
