摘要
本文探讨了血中性粒细胞(PMN)游离钙水平〔Ca^(2+〕_i的变化与烟雾吸入性损伤的关系,同时还观察了钙拮抗剂粉防己碱对游离钙水平的影响与减轻吸入伤作用的关系。发现致伤后,血PMN数目有一短暂下降后持续升高,支气管肺泡灌洗液中PMN数目却明显增加;血PMN〔Ca^(2+)〕_i水平也明显增加。粉防己碱可以减少肺内PMN数目,降低血PMN〔Ca^(2+)〕_i水平,并且减轻吸入性损伤。提示PMN的活化与吸入伤的病理生理改变密切相关,粉防己碱可能是通过降低PMN〔Ca^(2+)〕_i水平,调节PMN功能,发挥其治疗作用。
The changes of cytosolic free calcium in the peripheral neutro-phils after the rabbits were exposed to smoke inhalation were observed and the ptherapeutic effects of tetrandrine-a calcium antagonist?on the level of free calcium and on the injury also studied.It was found that the number of neu-trophils increased significantly in the peripheral blood after a transient drop and it also increased in the bronchoalveolar lavage fluid.The level of free calcium in the neutrophils were increased at the same time.Tetrandrine could reduce the number of neutrophils in the lungs,the calcium level in the neutrophils,and the severity of inhalation injury.The findings suggest that there is a close relationship between the activation of neutrophils and the pathophysiological manifestations of smoke inhalation injury,and tetrandrine can exert certain therapeutic effects on smoke inhalation injury through reducing the level of cytosolic free calcium in the neutrophlis to modulate their functions
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第1期1-5,共5页
Journal of Third Military Medical University
关键词
烧伤
吸入性
嗜中性白细胞
钙
兔
burns, inhala,tion
neutrophils
calcium
tetrandrine
rabbits
