摘要
目的 : 研究果寡糖 (FOS)对肥育猪胆固醇代谢的影响。方法 : 96头体重 45 kg左右的杜长加肥育猪按饲养试验要求分成 4组 ,每组设三个栏 ,每栏 8头猪 ,分别饲喂添加 0、0 .5 %、1 .0 %、1 .5 % FOS的饲粮 45 d。饲养试验结束后 ,从每组选出体重相近的 8头猪 (公母各半 )屠宰 ,测各项指标。结果 : (1 )添加 FOS使肥育猪日增重和饲料转化效率显著提高 ;(2 )添加1 .0 %和 1 .5 % FOS使血清中总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL- C)显著降低 ,使高密度脂蛋白胆固醇 (HDL - C) /低密度脂蛋白胆固醇 (LDL- C)的比率显著提高 ,添加 1 .5 % FOS使血清中极低密度脂蛋白胆固醇 (VLDL- C)、载脂蛋白 B(Apo B)和 Apo B/载 Apo A- 1显著降低 ;(3 )添加 1 .0 %和 1 .5 % FOS使肝脏中 3 -羟基 - 3 -甲基戊二酰辅酶 A(HMG- Co A)还原酶活性显著降低 ;(4)添加 1 .5 % FOS使结肠中乙酸、丁酸和血浆中乙酸含量显著提高 ,添加 0 .5 %、1 .0 %和 1 .5 %FOS使结肠中丙酸含量显著提高 ;(5 )添加 1 .0 %和 1 .5 %使粪便 FOS中胆固醇含量显著提高 ,添加 1 .5 % FOS使粪便中胆汁酸含量显著提高。结论 : FOS可能通过改变结肠发酵而抑制胆固醇的吸收和合成以及增加粪便中胆固醇和胆汁酸的排出 。
Objective: To study the effects of dietary fructooligosaccharide (FOS) on cholesterol metabolism in finishing pigs. Methods: A total of 96 finishing pigs (Duroc×Landrance×Jia) were randomly alotted to four groups each of which was replicated three times with eight pigs per replicate. The groups received the same basal corn-soybean meal diet and FOS was added to the basal diet at 0,0.5%,1 0%,1.5% at the expense of corn, respectively. At the end of the feeding trial, eight pigs with similar body weights from each treatment were slaughtered. Results: (1) Supplementation with FOS significantly improved average daily gain and feed efficiency. (2) Pigs fed 1.0% and 1.5% FOS had significantly lower serum TC and LDL-C concentrations and greater HDL-C/LDL-C ratio compared with the control. Pigs fed 1.5% FOS had significantly lower serum VLDL-C and ApoB concentrations and Apo B/Apo A-1 ratio. (3) Supplementation with 1.0% and 1.5% FOS significantly decreased the activities of HMG-CoA reductase. (4) Supplementation with 1.5% FOS significantly increased the colonic acetate and butyrate and plasma acetate. Supplementation with 0.5%,1.0% and 1.5% FOS significantly increased colonic propionate. (5) Fecal cholesterol excretion was significantly greater in the pigs fed 1.0% and 1.5% FOS and fecal bile acid excretion was significantly greater in the pigs fed 1.5% FOS than the control. Conclusion: FOS may improve cholesterol metabolism by alteration in the absorption and synthesis of cholesterol resulted from the changes in colonic fermentation, and by increase in the fecal excretion of cholesterol and bile acid.
出处
《营养学报》
CAS
CSCD
北大核心
2002年第4期393-397,共5页
Acta Nutrimenta Sinica
基金
国家自然科学基金资助项目 ( No.30 10 0 130 )
