摘要
作者过去曾注意到流行性出血热尸检病例脑内脂褐素似有增多现象,本研究的目的是通过尸检典型病例以及乳鼠实验来观察流行性出血热时脑内脂褐素有无增加.从尸检病例脑组织各取10个组织块.切片经苏丹Ⅳ及苏丹黑染色,与对照组切片中脂褐素含量进行比较.将流行性出血热病毒感染BALB/c乳鼠与对照组脑组织脂褐素含量比较,证明流行性出血热感染时脑组织中脂褐素沉积确有明显增加.鉴于脂褐素增加可见于发热期,感染显然是促其形成的因素.但低血压及休克是否发挥作用,也不能排除。
The authors noticed in the past that the lipofuscin of the brain seemed to have been increased in autopsy cases of epidemic hemorrhagic fever. The purpose of this study was to testify if there is really such an increase. Lipofuscin in 10 sections from every brain of 10 autopsy cases, stained by Sudan IV, Sudan black and H. E., was carefully estimated and found to be greatly increased as compared with the controls of the same ages without brain disease. Animal experiment was conducted on 15 suckling BALB/c mice by IP of 100 LD50 (0-05 ml) of Chen strain of hemorrhagic fever virus with 15 mice as controls. No lipofuscin was detected in the suckling control mice. But in the brains of experimental mice, lipofuscin was found to be markedly increased, specially in the necrotic cells. The over production and deposition of lipofuscin was thought to be a mild change caused by the virus and its related factors, perhaps also enhanced by hypotension and shock.
出处
《第四军医大学学报》
1992年第6期401-404,共4页
Journal of the Fourth Military Medical University
基金
国家自然科学基金 No.38970335
关键词
流行性出血热
脂褐质
病理学
hemorrhagic fever, epidemic
autopsy
brain
lipofuscin
pathology
mice, inbred BALB/c
