摘要
目的 :研究筛选改善高原移居青年肺通气功能的药物 ;方法 :对海拔 3 70 0m已习服的 40名士兵随机分为 4组 ,每组 1 0人 ,在上午让受试者用EGM型踏车功量机做坐位踏车运动 ,初始负荷功率 2 5W ,每 3min递增 50W ,递增至 2 2 5W踏车 3min后终止 ,计算每位受试者的肺通气量 (VEBTPS) ,然后 4组受试者分别口服酪氨酸、乙酰唑胺、依那普利加硝苯地平、安慰剂 (对照组 ) ,每天 2次 ,连服 1 5天 ,在服药 1 0天、1 5天、停药 1 0天、2 0天时重复上述运动实验 ,采用双因素方差分析 q检验 ;结果 :服药 1 0天、1 5天、停药 1 0天、2 0天时 ,酪氨酸组、乙酰唑胺组、依那普利组VEBTPS较服药前及对照组减少或明显减少 ,差别有显著性或差别有高度显著性 (P <0 .0 5或P <0 .0 1 ) ;结论 :酪氨酸、乙酰唑胺及依依那普利加硝苯地平均能提高高原移居青年的肺通气功能 ,其药物的良性作用可维持2 0天以上。
Objective:To study and select some medicine which could improve immigrants function of pulmonary ventilation at high altitude.Methods:40 subjects,who have stayed 3 700m altitude for 6 months were randomly divided into tyrosine group,acetazolamide group,enalapril+nifedipine group and placebo group,and constantly pedaled the EGM efficiency-bicycle as loaded exercise (initial load 25W,increase progressively 50W per 3 min to 225W),to calculate their ventilation volume before and after 10 days and 15 days,taking medicine and the testswere dore when the drugs were stopped for 10 and 20 days.Results:As compared with control group the pulmonary ventilation was significantly decreased in other groups (P<0.05 or P<0.01).Conclusion:There were some medicine,such as tyrosine,acetazolamide,enalapril and nifedipine,could improve the pulmonary ventilation function at high altitude,and could retain efficiency for 20 days.
出处
《高原医学杂志》
CAS
2002年第4期4-6,共3页
Journal of High Altitude Medicine
关键词
高原
酪氨酸
乙酰唑胺
依那普利
肺通气量
High altitude
Tyrosine
Acetazolamide
Enalapril
Pulmonary ventilation
