摘要
目的 :观察运用溶栓胶囊治疗前后高原红细胞增多症患者抗氧化能力及内皮功能的变化 ,探讨其对高原红细胞增多症发生、发展的影响 ;方法 :对 1 62例高原红细胞增多症患者治疗前后血清SOD、MDA、GSH和NO、NOS、ET -1含量进行测定 ,并与 3 3例高原正常健康人作对比研究 ;结果 :高原红细胞增多症患者血清SOD、GSH、NO及NOS含量在治疗前显著低于治愈后和对照组 (P <0 .0 1 ) ,MDA及ET -1含量治疗前显著高于治愈后和对照组 (P <0 .0 1 ) ,治愈后与对照组无明显差异 (P >0 .0 5) ;结论 :高原红细胞增多症患者机体处于氧化胁迫状态 ,脂质过氧化损伤及内皮功能失衡是HAPC患者病情持续加重的重要原因之一。溶栓胶囊可明显改善患者的内皮功能。
Objective:To study plasmin capsules on antioxidative capacity and endothelial function in patients with HAPC.Method:The subjects were assigned in treated group (162 cases with HAPC, 159 men, 3 women. Age range from 21～48 years, migrants) and control group (33 cases no evidence of HAPC and other disease, 31 men, 2 women). The serum level of SOD, MDA, GSH, NO, NOS and ET-1 were measured before and after administration with plasmin capsules in treated group as well as in no-administration control group.Results:The level of SOD, GSH, NO and NOS were lower significantly (P<0.01) after treatment than those in before treatment and control session. The level of MDA and ET-1 were higher significantly (P<0.01) before treatment than after treatment and control. All indices of test serum after treatment in patients with HAPC had no obvious changes (P< 0.05 ) compared with those in control group.Conclusion:The plasmin capsules could significantly improve the function of endothelium and decreased the damage of lipid superoxidation in patients with HAPC.
出处
《高原医学杂志》
CAS
2002年第4期33-35,共3页
Journal of High Altitude Medicine
