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急性脑血管病患者血清NSE测定及其临床意义 被引量：2

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摘要 目的 :评价脑血管病患者血清神经元特异性烯醇化酶 (NSE)水平及其临床意义。方法 :用ELISA法对 38例脑梗死及 13例脑出血患者发病后 1、2、3、15d和 2 7例正常对照血清NSE水平进行检测 ,并与脑损害大小及 1个月后ADL评分进行相关分析。结果 :脑血管病患者血清NSE水平明显高于正常对照 ,脑梗死患者血清NSE均值、峰值水平与梗死体积的相关系数分别为 0 77、0 81(P <0 0 1) ,两者与ADL的相关系数分别为 -0 35 (P <0 0 5 )、-0 37(P <0 0 5 ) ;脑出血患者则无此相关性。结论 :血清NSE可以反映脑梗死程度及其近期预后 。
作者 吴云成 乔健 谈永基 吕传真 赵永波
机构地区 上海市第一人民医院神经科 复旦大学附属神经病学研究所
出处 《中国临床神经科学》 2002年第4期381-384,共4页 Chinese Journal of Clinical Neurosciences
关键词 神经元特异性烯醇化酶 脑梗死 脑出血 预后
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献9

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同被引文献18

  • 1黄燕萍,李小权,王安生,康燕,罗树舫,史瑞明,辛华,李改莲,邓素莲.神经元特异性烯醇酶在早期评估新生儿缺氧缺血性脑病预后中的价值[J].新生儿科杂志,2005,20(1):23-26. 被引量：10
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33037
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  • 4[2]Wunderlich MT, Ebert AD, Kratz T, et al. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage[J]. Stroke,1999,30(6): 1190-1195.
  • 5[3]Butterworth R J, Wassif WS, Sherwood RA, et al. Serum neuron-specific enolase,carnosinase, and their ratio in acute stroke. An enzymatic test for predicting outcome[J]? Stroke, 1996,27(11 ):2064-2068.
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  • 9[8]Oh SH, Lee JG, Na S J, et al. Prediction of early clinical severity and extent of neuronal damage in anterior circulation infarction using the initial serum neuron-specific enolase level[J]. Arch Neurol, 2003, 60( 1 ):37-41.
  • 10Missler U,Wiesmann M,Friendich C,et al.S-100 protein and neuron-specific enolase concentration in blood as indicators of infarction volume and prognosis in acute ischemic stroke[J].Stroke,1997,28(10):1956-1960.

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中国临床神经科学
2002年 第4期

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