摘要
目的 复制饮茶型氟中毒动物病理模型。方法 通过生化学指标和组织病理学方法进行观察。结果 1实验组大鼠血、尿、骨氟含量均明显升高 ,与对照组相比差异有极显著意义 ( P <0 .0 0 1) ,且 10 0 %出现氟斑牙。2光镜下可见 ,饮砖茶水组大鼠胫骨干骺端骨小梁增多、变密 ,相互连接成网 ;肾近曲小管上皮细胞核萎缩、形态不规则 ;肝细胞浊肿变性 ;心肌纤维间隙增大。结论 长期大量饮用砖茶水确实可以引起氟中毒 ;砖茶氟不仅损害骨组织 ,造成氟斑牙和氟骨症 ,同时也影响体内多种组织器官的功能 ,尤以肾脏受损最为明显。
Objective To duplicate the animal model of drinking brick-tea type fluorosis.Methods The biochemical and histopathological methods were adopted.Results ①Compared with control group, the contents of fluoride in serum, urine and bone of experimental rats markedly increased and had greatly significant difference(P<0.001),and all rats suffered from dental fluorosis.②Under the optical microscope, we could see that in brick tea group, the trabecular bone of metaphysis in tibia increased and became dense, and connected each other; Nucleus of proximal convoluted tubule of kidney atrophied and their figures were irregular; Hepatocytes were cloudy swelling and degeneration; The distance among myocardial cells extended.Conclusions It was proved that fluorosis was surely caused by ingesting large amount of fluoride due to consumption of brick tea water as a beverage for a long time; fluorine in brick tea not only damaged hard tissues and caused dental fluorosis and skeletal fluorosis, but also affected many tissues and organs, especially kidneys.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2003年第1期22-24,共3页
Chinese Jouranl of Endemiology
