摘要
变形链球菌是人类龋病的主要致病菌,该菌在牙面粘附聚集并形成致龋性微生态环境-牙菌斑,进而导致龋病发生。变形链球菌粘附的表面粘附素主要有表面蛋白(PAc)、葡萄糖基转移酶(Gtf)等。针对这些粘附素设计的粘附抑制多肽为龋病的预防带来了一种全新的可能。本文就变形链球菌粘附素的特点及变形链球菌粘附抑制多肽的研究进展做一综述,有望建立一种简单、安全、有效的新型防龋方法。
Streptococcus mutans(S. mutans) is considered as a primary cariogenic bacterium. Its ability of adherence and further accumulation on teeth to generate dental biofilm constitutes an important condition for dental caries.Adhesins generated by S. mutans include cell surface protein antigen Ag I/II(PAc) and the glucosyltransferase(Gtf) enzyme, etc. A new possibility may be brought in to prevent dental caries with adhesion-blocking synthetic peptides designed specifically for such adhesions. In this paper, we summarize the characteristics of adhesins and make a survey of recent progress on adhesion-inhibiting peptides of Streptococcus mutans. We also propose a simple, safe and efficient way to prevent caries.
出处
《海南医学》
CAS
2016年第5期777-778,779,共3页
Hainan Medical Journal
基金
广东省医学科研基金立项课题(编号:A2013435)
广东医学院附属医院博士科研启动基金(编号BK201211)
关键词
变形链球菌
粘附
多肽
龋病
Streptococcus mutans
Adherence
Peptide
Dental caries
