摘要
目的探究血清降钙素原(PCT)和C反应蛋白(CRP)对癌症化疗后腹泻患者肠原性细菌感染的检测价值。方法将我院2012年1月至2014年6月就诊的42例化疗后腹泻患者作为观察组进行腹泻等级评估,其中1级17例,2级13例,3级8例,4级4例;58例化疗后无腹泻患者作为对照组。采用化学免疫发光法检测PCT水平,免疫散射比浊法检测CRP水平。比较各组患者血清PCT和CRP含量。结果观察组腹泻1级到4级PCT、CRP含量逐渐升高,对照组与观察组腹泻1级、2级比较,PCT、CRP水平差异均无统计学意义(P<0.05),对照组、观察组腹泻1级、2级与观察组3级、4级PCT、CRP水平差异均有统计学意义(P<0.05)。观察组PCT阳性率为88.09%(37/42),明显高于对照组的12.07%(7/58),差异具有统计学意义(P<0.05);观察组CRP阳性率为95.23%(40/42),明显高于对照组的51.72%(30/58),差异具有统计学意义(P<0.05)。结论癌症化疗后腹泻患者血清PCT和CRP对诊断腹泻肠原性细菌感染具有一定的临床参考价值,为临床应用提供了一定的科学依据。
Objective To study the detection value of procalcitonin(PCT) and C-reactive protein(CRP) in enterogenous bacterial infections among cancer diarrheal patients after chemotherapy. Methods A total of 42 cases of cancer diarrheal patients, who admitted to our hospital from January 2012 to June 2014, were selected as the observation group. After the treatment of chemotherapy, these patients were evaluated the diarrhea grade and divided into 17 cases of grade 1, 13 cases of grade 2, 8 cases of grade 3 and 4 cases of grade 4. Fifty-eight cases of patients without diarrhea were selected as the control group. The PCT and CRP levels were detected respectively by chemiluminescence immunoassay(CLIA) and turbidimetric inhibition immunoassay(TINIA), and the difference of serum PCT and CRP between groups were compared. Results The PCT and CRP levels of diarrhea grade 1 to grade 4 in the observation group gradually increased. There was no significant difference between the two groups in diarrhea grade 1 and 2(P>0.05). There was significant difference between the grade 1, 2 and grade 3, 4 in the two groups(P<0.05). PCT and CRP positive rates in the observation group were significantly higher than those in the control group 88.09%(37/42) vs 12.07%(7/58), 95.23%(40/42) vs 51.72%(30/58), P<0.05. Conclusion Serum PCT and CRP can help estimate diarrhea enterogenous bacterial infection in patients with cancer after chemotherapy, and provide a scientific basis for clinical application.
出处
《海南医学》
CAS
2016年第19期3129-3130,3131,共3页
Hainan Medical Journal
关键词
癌症
腹泻
血清降钙素原
C反应蛋白
肠原性细菌感染
Cancer
Diarrhea
Serum procalcitonin
C-reactive protein(CRP)
Intestinal bacterial infection
