摘要
目的探讨血清甲状腺球蛋白(Tg)及抗甲状腺球蛋白抗体(Tg Ab)水平对分化型甲状腺癌伴发桥本甲状腺炎患者癌转移的预测价值。方法选取2008年1月至2012年6月我院收治的90例分化型甲状腺癌伴发桥本甲状腺炎的患者,甲状腺全切术联合碘消融治疗后随访3年收集癌转移情况。分析不同血清Tg水平下Tg Ab阳性(>40 k IU/L)预测患者有无癌转移的危险度比值(OR)。结果 Tg≤1μg/L组患者中,Tg Ab阳性相对于阴性患者的癌转移危险度(OR)值为27.0(95%CI:4.02~181.4),Tg Ab水平与甲状腺癌癌转移高度相关;1μg/L<Tg≤10μg/L组患者中,Tg Ab阳性相对于阴性患者的癌转移OR值为6.7(95%CI:1.04~42.43),Tg Ab水平与甲状腺癌癌转移相关;10μg/L<Tg≤100μg/L组患者中,Tg Ab阳性相对于阴性患者的癌转移OR值为2.0(95%CI:0.14~26.71),Tg Ab水平与甲状腺癌癌转移无相关;Tg>100μg/L组患者均为Tg Ab阴性,Tg Ab水平与甲状腺癌癌转移无相关。结论对于Tg≤1μg/L的老年分化型甲状腺癌伴发桥本甲状腺炎患者,Tg Ab阳性(>40 k IU/L)预测甲状腺癌转移的价值较高。
Objective To study the predictive value of thyroglobulin(Tg) and antithyrogloblin antibody(Tg Ab) level on metastasis in patients of differentiated thyroid carcinoma(DTC) complicated with Hashimoto's thyroiditis. Methods Ninety patients with DTC complicated with Hashimoto's thyroiditis in our hospital from January 2008 to June 2012 were selected, which were treated with total thyroidectomy combined with radioactive iodine ablation and were then followed up for three years to collect data of cancer metastasis. The patients were divided into four groups(according to the level of Tg): Tg≤1 μg/L group, 1 μg/L<Tg≤10 μg/L group, 10 μg/L<Tg≤100 μg/L group, Tg>100 μg/L group. Odds ratio(OR) was used to evaluate the value of Tg Ab positive(>40 k IU/L) for predicting cancer metastasis in patients with different levels of serum Tg. Results In Tg≤1 μ g/L group, the OR was 27.0(95% CI: 4.02~181.4) for Tg Ab positive to Tg Ab negative in predicting cancer metastasis, and the levels of Tg Ab was highly correlated with the metastasis of thyroid carcinoma. In 1 μg/L<Tg≤10 μg/L group, the OR was 6.7(95%CI: 1.04~42.43) and the level of Tg Ab was related to the metastasis of thyroid cancer. In 10 μg/L<Tg≤100 μg/L group, the OR was 2.0(95%CI: 0.14~26.71) and Tg Ab level had no correlation with metastasis of thyroid cancer. In Tg>100 μg/L group, the patients were all Tg Ab negative, and Tg Ab levels had no correlation with metastasis of thyroid cancer. Conclusion The value of Tg Ab positive(>40 k IU/L) in predicting cancer metastasis is relatively high for elderly patients of differentiated thyroid carcinoma complicated with Hashimoto's thyroiditis with Tg≤1 μg/L.
出处
《海南医学》
CAS
2016年第19期3134-3136,共3页
Hainan Medical Journal
关键词
甲状腺球蛋白
抗甲状腺球蛋白抗体
分化型甲状腺癌
桥本甲状腺炎
预测价值
Thyroglobulin(Tg)
Antithyrogloblin antibody(TgAb)
Differentiated thyroid carcinoma(DTC)
Hashimoto's thyroiditis
Predictive value
