摘要
观察用心得安(21例)、哌唑嗪(12例)和硝苯吡啶(18例)分组治疗高血压病治疗前后病人血脂水平及脂酶活性的变化表明:心得安可升高 TG、TC 及 LDL-C 水平,降低 HDL-C/TC 比值,抑制 LPL 活性;哌唑嗪升高 HDL-C水平及 HDL-C/TC 比值,降低 TG、TC 和 LDL-C 水平同时,增强 LPL 和H-TGL 活性;硝苯吡啶降低 TG、TC 和 LDL-C 水平。提示:长期应用利尿剂与心得安等β受体阻滞剂治疗高血压病不恰当,而哌唑嗪是目前治疗高血压病或高血压病合并高脂血症较好的药物。
The change of blood fat lipase activity before and after inderal(21 cases),prazosin(12 cases),and nifedipine(18 cases)for the treatment of hypertension disease respectively showed:Inderal could increas TG,TC and LOL-C level,decrease HDL-C/TC ratio and inhibit LPL activity;prazosin could increase HDL-C level and HDL-C/TC ratio,decrease TG,TC and LDL-C level,enhance LPL and H-TGL activity;and nifedipine could decrease TG,TC and LDL-C level,it is indicated that diurectic and β acceptor blocking agent such as inderal for a long-term treatment of hyper tension disease is not suitable,but prazosin is now commended to treat hypertension disease or hypertension disease complicated with hight blood fat.
出处
《武汉大学学报（医学版）》
CAS
1988年第3期238-241,共4页
Medical Journal of Wuhan University
