摘要
目的:为加深了解胃肠道神经内分泌癌的形态学特征和生物学行为及临床表现与治疗,通过有关酶标的检测预示其预后。方法:回顾分析1999年3月～2000年6月本科收治的15例胃肠道神经内分泌癌资料。结果:1例行根治性全胃切除术,4例行根治性胃次全切除术,(其中1例术后3个月出现肝转移和腹水,但仍存活);2例晚期患者仅行剖腹探查,淋巴结或大网膜活检术,分别于术后4个月和5个月死亡;2例行部分小肠切除术;2例行根治性右半结肠切除术,(其中1例于术后5个月死亡,1例术后4个月出现肠瘘,后死于衰竭);2例行经腹会阴直肠切除术;2例行直肠前切除术。10例生存至今21～35个月。结论:胃肠道神经内分泌癌的临床症状、体征、内镜或GI检查结果及目前治疗方法均与胃肠道腺癌相似,并无明显特异,而通过病理检查及有关酶标的检测可明确诊断及预示其恶性程度和预后。
Objective: To investigate the biological behaviour and morphological characteristics of gastrointestinal neuroen-docrinal carcinoma, as well as its clinical manifestation and treatment, and to evaluate the value of enzymatic markers as a prognostic marker. Methods: 15 cases admitted in Zhongshan Hospital from March 1999 to June 2000 with gastrointestinal neuroendocrinal carcinoma were collected for retrospective analysis. Results: 1 case underwent radical total gastrectomy. 4 cases received radical subtotal gastrectomy, while one of them showed liver metastasis and ascites at 3 months postoperatively and still survive today. For 2 cases at end - stage underwent exploratory laparotomy, only lymph node biopsy or omental biopsy was performed and they died at 4 and 5 months after operation respectively. Segmental intestinal resection was performed for another 2 patients. 2 cases underwent radical right hemicolectomy, but one died 5 month postoperatively and the other suffered enteral fistula 4 month after operation and died from cachexia. Abdominoperineal proctosigmoidectomy was performed in 2 cases , and anterior proctosigmoidectomy was adopted for 2 cases. There are 10 patients surviving till now, with the period of 21 -35 months. Conclusion: Clinical symptoms, signs, endoscopic or gastrointestinal series findings of gastrointestinal neuroendocrinal carcinoma are similar to those of gastrointestinal adenocarcinoma, and so is the treatment. But pathological examinations, especially enzymatic makers, are diagnostic, and thus indicate the malignancy and prognosis.
出处
《中国临床医学》
2002年第6期634-636,共3页
Chinese Journal of Clinical Medicine
