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动脉溶栓治疗急性颈内动脉闭塞所致缺血性脑梗死 被引量:5

Intra-arterial Thrombolysis in Patients with Acute Ischemic Stroke of the Cervical Internal Carotid Artery Occlusive Disease
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摘要 目的观察动脉溶栓治疗急性颈内动脉闭塞所致缺血性脑梗死的疗效及并发症。方法对10例发病在6h内的患者行动脉溶栓治疗,并对其中2例辅以经皮腔内血管成形术(PTA)或颈动脉内膜剥脱术(CEA)治疗。血管再通程度用TIMI分级评价。临床结果评价在溶栓后30d进行,根据ModifiedRankinScale(MRS)分类。结果溶栓前10例患者均为TIMI0~1,溶栓后8例部分/完全再通,其中7例结果良好(MRS0~3)。发生症状性脑出血2例(10%)。结论症状发作6h内的动脉溶栓可明显改善急性颈内动脉闭塞所致缺血性脑梗死患者的预后,降低死亡率。 Objective To observe the safety and efficacy of local intra-arterial thrombo lysis(LIT)in patients with acute ischemic stroke of cervical internal carotid artery occlusive disease.Methods 10patients were treated by LIT.2of10pati ents were further treated by either angioplasy or endarterectomy.Primary neuror adiological assessment was performed with CT in all patients.Angiographic reca nalization level was classified according to thrombolysis in myocardial infarcti on(TIMI )grades.Clinical outcome was classified as good for Modified Rankin Scale(MRS)scores of0to3and as poor for MRS scores of4to6.Results Complete /partial recanalization after infusion was accomplished in8patients,seven of w hom had good clinical outcome.Cerebral hemorrhage occurred in2of10patients. Conclusion The results of this study suggest that LIT may be helpful to improve the outcome in patients with acute cervical internal carotid artery occlusive disease if it is performed within6hours of stroke onset.
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2002年第6期646-649,I002,共5页 Acta Academiae Medicinae Sinicae
基金 国家"九五"科技攻关项目(96-907-02-03)
关键词 急性颈内动脉闭塞 动脉内溶栓 急性缺血性脑卒中 疗效 并发症 intra-art erial thrombolysis acute ischemic stroke cervical internal carotid artery
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  • 1Meyer FB,Piepgras DG,Sandok BA, et al. Emergency carotid endarterectomy for patients with acute carotid occlusion and profound neurological deficits.Ann Surg,1986,203:82-89
  • 2Shunro E, Naoya K, Yutaka H, et al. Results of urgent thrombolysis in patientswith major stroke and atherothrombotic occlusion of the cervical internal carotid artery. Am J Neuroradiol, 1998,19:1169-1175
  • 3Gary M Nesbit, Wayne M Clark, Oisin RO, et al. Intracranial intraarterial thrombolysis facilitated by microcatheter navigation through an occluded cervical internal carotid artery. J Neurosurg,1996,84:387-392
  • 4TIMI study group. Special report:the thrombolysis in myocardial infarction(TIMI)trial. N Engl J Med, 1985;312:932-936
  • 5Goldstein LB, Bertels C, Davis JN. Interrater reliability of NIH Stroke Scale. Arch Neurol,1989,46:660-662
  • 6Rankin J. Cerebral vascular accidents in patients over the age of 60,Ⅱ: prognosis. Scott Med J, 1957,2:200-215
  • 7Tong DC, Yenari MA ,Albers GW, et al. Correlation of perfusion-and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke.Neurology,1998,50(4):864-870
  • 8Toshihiro U, Saburo.S, Yoshiaki K, et al. Multivariable analysis of predictive factors related to outcome at 6 months after intra-arterial thrombolysis for acute ischemic stroke.Stroke,1999,30:2360-2365
  • 9The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med, 1995,333:1581-1587
  • 10Gregory J d Z, Randall T H, Anthony.J.F, et al. Proct:A PhaseⅡrandomized trial of recombinant pro-urokinade by direct arterial delivery in acute middle cerebral artery Stroke.Stroke,1998,29:4-11

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