摘要
目的探讨遗传因素在系统性红斑狼疮发病中的作用.方法应用病例对照研究方法对166例SLE 先证者和383例对照的亲属资料进行遗传流行病学研究.结果12.05%的先证者的一级亲属患有SLE.一级亲属、二级亲属患病率依次为1.698%、0606%,显著高于对照组一级亲属患病率(0.115%)(P＜0.01),其OR值及95%可信区间分别为14.88(4.22～62.70)、5.31(1.38～23.95),日一级亲属患病率＞二级亲属患病率＞三级亲属患病率＞群体患病率.应用Penrose方法计算,s/q接近1/√q.Falconer多基因阈值模型估计SLE先证者一级、二级、三级亲属的遗传度分别为78.8%±4.45%、58.8%±10.9%、39.2%±32.0%,三者加权平均遗传度为75.2%±4.12%.结论SLE具有多基因遗传病的特点,遗传因素在决定SLE的易患性上起到重要的作用.
Objective To explore the significance of genetic factor in the pathagenesis of systemic lupus erythematosus(SLE).Methods A case-control study of166SLE probands and383controls was performed to analyze the effect of genetic factor on the liability of SLE.Falconer's methed was used to estimate the heritability.Results20(12.05%)of166probands had one or more first-degree relatives suffered from SLE.Prevalence rates of SLE in first-degree relatives and second-degree relatives in proband group were1.698%and0.606%,respectively,which were significantly higher than that in control group(0.1115%)(P<0.01).Furthermore,the odd ratio(OR)and its95%confidence interval(95%CI)were14.88(4.22~62.70)and5.31(1.38~23.95),respectively.The order of prevalence rates was as follows:first-degree relatives>second-degree relatives>third-degree relatives>control relatives.A ratio of s/q approached1/q with Penrose' s method.Heritability of SLE was78.8%±4.45%in the first-degree relatives,58.8%±10.9%in the second-degree relatives,and39.2%±32.0%in the third-degree relatives.The weighted mean heritability was75.2%±4.12%.Conclusions SLE has characteristics of polygenic disease.Genetic factor might play an important role in the liability of SLE.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2003年第1期7-9,共3页
Chinese Journal of Dermatology
基金
安徽省自然科学基金(98437231)
安徽省高等学校自然科学基金(98JL080)
