摘要
目的 :建立测定苦参素血药浓度的HPLC法并研究苦参素注射液在健康人体内的药物动力学。方法 :18名健康男性受试者 ,肌注 30 0mg药物后 ,采用HPLC法测定血药浓度 ,用 3p87软件经微机处理药 时数据。 结果 :苦参素注射液的体内过程符合二室模型。结论 :此法提供了苦参素注射液在健康人体中的药动学数据。
OBJECTIVE To established a method for determining oxymatrine in human plasma and to study the pharmacokinetics of matrine injection. METHODS 18 male health volunteers was given with a single dose of 300 mg oxymetrine. The serum concentrations of oxymetrine were determined by HPLC. Data of serum level-time were disposed with 3p 87 software. RESULTS The serum concentration-time curve of the oxymetrine injection appeared to fit two-compartment open model. CONCLUSIONS The present study provides pharmacokinetics of matrine injection in healthy volunteers.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2003年第1期21-22,共2页
Chinese Journal of Hospital Pharmacy
