摘要
目的探究糖代谢异常与甲状腺体积增大和甲状腺结节患病率的相关性。方法选取2011-01/2013-12月在作者医院诊治的糖尿病前期患者134例和2型糖尿病患者106例,同时选取健康成人98名作为对照组。收集受试者临床资料,同时超声检测甲状腺体积和结节情况。结果三组受试者年龄、性别构成、吸烟史等临床特征无显著差异,糖尿病前期患者和2型糖尿病患者体质量指数(body mass index,BMI)、腰围(waist circumference,WC)、甲状腺体积和甲状腺结节患病率均高于对照组。相关性分析显示,甲状腺结节体积与年龄、吸烟史、BMI、WC、胰岛素抵抗指数(insulin resistance index,Homa-IR)呈正相关;甲状腺结节患病率与性别(男vs女)呈负相关,与年龄、吸烟史、BMI、WC、HOMA-IR呈正相关。同时,多元线性回归和logistic回归分析结果显示,年龄、BMI、糖尿病前期和2型糖尿病与甲状腺体积、甲状腺结节患病率独立相关,患有糖尿病前期和2型糖尿病的病人发生甲状腺结节的风险较高,比值比分别为3.23和4.13。结论糖代谢异常是甲状腺形态异常和甲状腺结节发生发展过程中的关键因素。
Objective To investigate the association of impaired glucose metabolism with increased thyroid volume and nodule prevalence.Methods A total of 134 patients with pre-diabetes,106 patients with type 2 diabetes mellitus and 98 subjects with normal glucose metabolism between January 2011 to December 2013 in the authors' department were recruited.Clinical characteristics were gathered and thyroid ultrasonography was performed in all participants.Results There was no significant difference in age,gender,smoke history among three groups.Body mass index(BMI),waist circumference(WC),thyroid volume,and nodule prevalence of the patient with pre-diabetes or type 2 diabetes mellitus were higher than that of the control group.Thyroid volume was correlated positively with age,smoke history,BMI,WC,and insulin resistance index(Homa-IR),and nodule prevalence was negatively correlated with gender(male vs female) whilepositively correlated with age,smoke history,BMI,WC,and Homa-IR.Multiple linear regression and multivariate binary logistic regression analyses suggested age,BMI,pre-diabetes diagnosis,and type 2 diabetes mellitus diagnosis were associated with the risk of the increased thyroid volume and nodule prevalence,and the odds ratios were 3.23 and 4.13 respectively.Conclusions The impaired glucose metabolism played a critical role in the changes of thyroid morphology and in the development of nodule.
出处
《华南国防医学杂志》
CAS
2015年第5期356-359,共4页
Military Medical Journal of South China
关键词
糖代谢异常
甲状腺体积
甲状腺结节
Impaired glucose metabolism
Thyroid volume
Nodule prevalence
