摘要
目的研究早期预警分级干预对高血压脑出血患者代谢指标及炎性因子的影响。方法选取我院2010-07—2013-07高血压脑出血患者108例,抽签随机分为干预组与对照组,每组54例,干预组实施早期预警干预,对照组不实施早期预警干预,比较2组患者治疗前后脑氧代谢指标水平变化,和治疗前后血清中炎性因子白细胞介素-1β(IL-1β)、白介素-6(IL-6)、高敏C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)等炎性因子水平。结果干预组患者的动脉-颈内静脉球部血氧差、脉搏氧饱和度、氧摄取率等脑氧代谢指标水平较对照组显著较高(P<0.05),脑氧摄取率、脑氧含量较对照自显著较低(P<0.05);干预组患者的IL-1β、IL-6、CRP、TNF-α等炎性因子水平较对照组均显著较低(P<0.05)。结论早期预警分级干预治疗高血压脑出血,可有效改善患者脑氧代谢情况,降低炎性因子水平,能及时对高血压脑出血患者的病情进行评估调整治疗方案,对患者的预后有一定预测能力,有临床应用推广价值。
Objective To study the effect of early warning grading intervention on metabolic indexes and inflammatory factors in patients with hypertensive cerebral hemorrhage.Methods A total of 108 cases of patients with hypertensive cerebral hemorrhage who were admitted in our hospital between July 2010 and July 2013 were selected and randomized into intervention group and control group,54 cases in each group.Patients in the intervention group were given early warning intervention,and the control group were not given early warning intervention.The changes of cerebral oxygen metabolic indexes,the levels of serum inflammatory cytokines[interleukin-1β(IL-1β),interleukin-6(IL-6),high-sensitivity C-reactive protein(CRP),tumor necrosis factor alpha(TNF?α)etc.]before and after treatment were compared between the two groups.Results The levels of blood oxygen difference in artery-internal jugular venous bulb,pulse oxygen saturation,oxygen uptake rate and cerebral oxygen metabolic indexes in the intervention group were significantly higher than those in the control group(P< 0.05)while cerebral oxygen uptake rate and cerebral oxygen content were significantly lower than those in control group(P< 0.05);The levels of IL-1,IL-6,CRP,TNF?αand other inflammatory factors in the intervention group were significantly lower than those in the control group(P< 0.05).Conclusion The application of early warning grading intervention in the treatment of hypertensive cerebral hemorrhage can effectively improve cerebral oxygen metabolism,reduce the levels of inflammatory factors and timely adjust the treatment regimen according to the progress of hypertensive cerebral hemorrhage in patients.It can be used to predict the prognosis and has clinical application value.
出处
《中国实用神经疾病杂志》
2016年第13期19-21,共3页
Chinese Journal of Practical Nervous Diseases
基金
基于社区高血压信息化管理的脑出血早期预警分级干预研究
编号:C201503
关键词
预警分级
高血压脑出血
代谢
炎性因子
Early warning grading
Hypertensive cerebral hemorrhage
Metabolism
Inflammatory factor
