期刊文献+

洛铂联合多西他赛治疗复发性卵巢癌的疗效 被引量:12

Clinical study on chemotherapy of lobaplatin combined with docetaxel in patients with relapsed ovarian cancer
下载PDF
导出
摘要 目的:了解洛铂联合多西他赛在复发性卵巢癌患者中的疗效和安全性。方法:在2011年1月至2013年1月之间,收集31例在湖南省肿瘤医院经组织病理学或细胞学诊断为复发性卵巢癌的患者。31例患者在接受洛铂联合化学治疗(化疗)前均接受了以顺铂或卡铂为基础的联合化疗方案。治疗中多西他赛80 mg/m2,第1天静脉化疗,洛铂为30 mg/m2,第2天静脉化疗,21 d为1个周期,最多进行6个周期的治疗,31例患者共完成153个周期的化疗。分析治疗后的总有效率、疾病控制率、无进展生存期和毒副作用。结果:31例患者中3例达到了完全缓解,11例部分缓解,2例疾病稳定,15例疾病进展,总有效率为45.16%(95%CI:26.61%~63.72%),DCR为51.63%(95%CI:32.98%~70.25%),中位无进展生存期为7个月(95%CI:4.27~9.73个月)。毒副作用中:1例3级白细胞减少,21例1~2级白细胞减少,18例1~2级中性粒细胞减少,17例1~2级贫血,2例1级血小板减少;消化道反应恶心、呕吐的发生较为温和且可以控制。未见严重的肝肾功能损伤。结论:洛铂联合多西他赛对复发性和难治性卵巢癌具有较好的抗肿瘤效应,疗效明显优于其他二线化疗方案,且具有较低的毒副作用。 Objective: To evaluate the efficacy and safety of lobaplatin combined with docetaxel in the treatment of the recurrent ovarian carcinoma. Methods: We collected 31 patients who diagnosed as recurrent ovarian carcinoma according to the histopathology or cytology from Tumor Hospital of Hunan Province from January 2011 to January 2013. The patients received cisplatin-based chemotherapy or carboplatin-based chemotherapy before the combined chemotherapy of docetaxel and lobaplatin. For patients with the recurrence, they received a treatment at a dose of 80 mg/m2 for docetaxel on day 1 and a dose of 30 mg/m2 for lobaplatin on day 2, which lasted for 21 days as a treatment cycle. hTe patients received 6-cycletreatment at most. Results: A total of 153 cycles of chemotherapy were given to 31 patients, with a median of 4 (2–6) cycles. Three patients showed complete response, 11 partial response, 2 stable disease, and 15 progressive disease. hTe objective response rate (ORR) was 45.16% (95% CI, 26.61%–63.72%), and the disease control rate (DCR) was 51.63% (95% CI, 32.98%–70.25%). The median progression-free survival was 7 months (95% CI, 4.27–9.73 months). For the toxic and side effects among the 31 patients, the numbers of the grade 3, grade 2, and grade 1 leukopenia were 1, 8, and 13, respectively. Meanwhile, 18 were grade 1–2 neutropenia, 17 grade 1–2 anemia, and 2 grade 1 thrombocytopenia. At the same time, alimentary canal reaction followed by nausea and vomiting was relatively modest and could be controlled. hTe serious damage of hepatic-renal function was not found. Conclusion: The chemotherapy of lobaplatin combined with docetaxel is effective on recurrent and refractory ovarian cancer with low side effects, which has advantages over the second-line chemotherapy protocols.
出处 《中南大学学报(医学版)》 CAS CSCD 北大核心 2014年第11期1131-1136,共6页 Journal of Central South University :Medical Science
关键词 复发性卵巢癌 洛铂 多西他赛 relapsed ovarian cancer lobaplatin docetaxel
  • 相关文献

参考文献8

  • 1吴坚文,杜志强,李丹,曾波航.洛铂联合多西他赛治疗复发转移性卵巢癌的疗效[J].广东医学,2013,34(6):944-946. 被引量:20
  • 2杨柳青,秦叔逵.第3代铂类药物洛铂的研究新进展[J].临床肿瘤学杂志,2009,14(12):1134-1139. 被引量:108
  • 3Guo Xian Long,Jing Wen Lin,Dong Bo Liu,Xiao Yi Zhou,Xiang Lin Yuan,Guang Yuan Hu,Qi Mei,Guo Qing Hu.Single-arm, multi-centre phase II study of lobaplatin combined with docetaxel for recurrent and metastatic nasopharyngeal carcinoma patients[J].Oral Oncology.2014
  • 4Andrew Wang,Chunbai He,Demin Liu,Wenbin Lin.Application of liposomal technologies for delivery of platinum analogs in oncology[J].International Journal of Nanomedicine (default).2013(default)
  • 5Cheng-Ying Xie,Yong-Ping Xu,Wei Jin,Li-Guang Lou.Antitumor activity of lobaplatin alone or in combination with antitubulin agents in non-small-cell lung cancer[J].Anti-Cancer Drugs.2012(7)
  • 6Bin Zhou,Hong Shan,Kang-Shun Zhu,Zai-Bo Jiang,Shou-Hai Guan,Xiao-Chun Meng,Xian-Cheng Zeng.Chemoembolization with Lobaplatin Mixed with Iodized Oil for Unresectable Recurrent Hepatocellular Carcinoma after Orthotopic Liver Transplantation[J].Journal of Vascular and Interventional Radiology.2010(3)
  • 7Phuong Dinh,Paul Harnett,Martine J. Piccart-Gebhart,Ahmad Awada.New therapies for ovarian cancer: Cytotoxics and molecularly targeted agents[J].Critical Reviews in Oncology and Hematology.2008(2)
  • 8Andreas Harstrick,Carsten Bokemeyer,Martin Scharnofkse,Gunnar Hapke,Dagmar Reile,Hans-Joachim Schmoll.Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines[J].Cancer Chemotherapy and Pharmacology.1993(1)

二级参考文献43

共引文献126

同被引文献85

  • 1第16届FIGO会议纪要(妇科恶性肿瘤TNM分期)[J].中国妇产科临床杂志,2001,2(1):62-64. 被引量:13
  • 2伍志新,宋文军,许玉香,黄彬彬.洛铂联合替吉奥治疗晚期胃癌的临床观察[J].环球中医药,2013,6(S2):129-129. 被引量:4
  • 3Chua TC, Esquivel J, Pelz JO, et al. Summary of current therapeutic options for peritoneal metastases from colorectal cancer[J]. J Surg oncol, 2013, 107(6): 566-73.
  • 4Sugarbaker PH. Surgical responsibilities in the management of peritoneal carcinomatosis[J]. J Surg oncol, 2010, 101(8): 713-24.
  • 5Glehen O, Osinsky D, Cot te E, et al. Int raperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures[J]. Ann Surg Oncol, 2003, 10(8): 863-9.
  • 6Elias D, Bonnay M, Puizillou JM, et al. Heated intra-operative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis: pharmacokinetics and tissue distribution[J]. Ann Oncol, 2002, 13(2): 267-72.
  • 7El-Kareh AW, Secomb TW. A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance[J]. Neoplasia, 2004, 6(2): 117-27.
  • 8Huang CQ, Feng JP, Yang X, et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from colorectal cancer: a case-control study from a Chinese center[J]. J Surg Oncol, 2014,109(7): 730-9.
  • 9Coccolini F, Campanati L, Catena F, et al. Hyperthermic intraperitoneal chemotherapy with cisplatin and paclitaxel in advanced ovarian cancer: a multicenter prospective observational study[J]. J Gynecol Oncol, 2015, 26(1): 54-61.
  • 10Ali I, Wani WA, Saleem K, et al. Platinum compouds: a hope for future cancer chemotherapy[J]. Anticancer Agents Med Chem,2013, 13(2): 296-306.

引证文献12

二级引证文献65

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部