摘要
目的 :探讨急诊PCI应用前列地尔脂微球载体制剂(凯时)对急性心肌梗死再灌注的影响。方法 :选择2012年2月~2014年10月本院行急诊PCI的急性ST段抬高心肌梗死患者100例,随机分为对照组和试验组,每组各50例,对照组给予替罗非班500μg导管内注入,试验组在应用替罗非班的基础上,术中冠脉内给予替罗非班+前列地尔,术前开始用前列地尔静脉滴注(20μg/次,2次/d)至术后48h。结果 :试验组TMPG3级血流比例明显高于对照组,试验组单导ST段回落指数高于对照组,两组差异有统计学意义。结论 :前列地尔可有效改善急性ST段抬高心肌梗死(AMI)后心肌再灌注,降低住院期间心血管事件的发生率,出血及心脏不良事件的发生无增加,值得在临床上推广使用。
Objective To explore the effect of Alprostadil lipid drug-loaded microcapsules injection on ischemia reperfusion in patients with STEMI undergoing percutaneous coronary intervention(PCI).Methods 100 patients who received PCI in our hospital from February 2012 to October 2014 were randomly divided into two groups,50 patients in each group.Tirofiban 500μg was administrered into the contral group.On the base of therapy of Tirofiban,patients of the experimental group receiving Alprostadil lipid drug-loaded microcapsules injection(20 μg,bid) by intravenous infusion twice a day for 48 hours..Alprostadil(10μg) was injected into intracoronary during PCI.Results The rate of TMPG 3 level perfusion in the experimental group(P<0.05)were obviously higher than those in the control group.The single-lead ST segment fall back index of the Alprostadil group was higher than those in the control group.Conclusion Alprostadil Injection can effectively improve reperfusion in patients with STEMI.Reduce the incidence of cardiovascular events during hospitalization.It’s deserved the clinical expansion.
出处
《湖南师范大学学报（医学版）》
2015年第3期79-80,81,共3页
Journal of Hunan Normal University(Medical Sciences)
