摘要
目的 :研究地佐辛联合右美托咪定在腹腔镜阑尾切除术后镇痛效果及对患者应激反应的影响。方法 :选取2015年1月～2017年1月期间在我院接受腹腔镜阑尾切除术的60例患者作为研究对象,根据随机数表法分为对照组、观察组,各30例。两组患者均接受腹腔镜阑尾切除术治疗,对照组患者术后采用0.8mg/kg地佐辛+5mg/kg丙泊酚+8mg托烷司琼+0.9%氯化钠注射液配制成100mL的接自控静脉镇痛进行镇痛;观察组患者术后应用0.5μg/kg右美托咪定+0.8mg/kg地佐辛+8mg托烷司琼+0.9%氯化钠注射液配制成100mL的接自控静脉镇痛进行镇痛。比较两组患者术后镇痛、镇静效果及应激反应指标变化、不良反应发生率。结果 :术后观察组患者VAS评分、Ramsay评分均低于对照组,差异有统计学意义;术后观察组患者的去甲肾上腺素、多巴胺水平均低于对照组,皮质醇、肾上腺素水平均高于对照组,差异有统计学意义;观察组患者不良反应发生率10.0%(3/30)低于对照组的33.3%(10/30),差异有统计学意义。结论 :地佐辛联合右美托咪定在腹腔镜阑尾切除术后镇痛效果显著,能有效减轻机体疼痛及应激反应,安全性高。
Objective To study the analgesic effect of dezocine combined with dexmedetomidine in laparoscopic appendectomy and its effect on stress response in patients. Methods 60 cases of patients undergoing laparoscopic appendectomy in our hospital from January 2015 to January 2017 were selected as subjects. All patients were divided into control group and observation group according to the random number table method, 30 cases in each group. Two groups of patients were treated by laparoscopic appendectomy, and the patients in the control group were treated with 0.8 mg/kg dorshensen + 5 mg/kg propofol + 8 mg tropisetron + 0.9% sodium chloride injection into 100 ml controlled intravenous analgesia for analgesia. The patients in the observation group were treated with 0.5 mg/kg dextromethorphan + 0.8 mg/kg dizosin + 8 mg tropisetron + 0.9% sodium chloride injection into 100 ml controlled intravenous analgesia for analgesia. The changes of postoperative analgesia, sedation and stress response were observed, and the incidence of adverse reactions was compared. Results The VAS score and Ramsay score of the postoperative observation group were lower than those of the control group, the difference was statistically significant. The levels of norepinephrine and dopamine in the postoperative group were lower than those in the control group, and the levels of cortisol and adrenaline were significantly higher than those of the control group. The incidence of adverse reactions in the observation group was 10.0%(3/30) lower than that in the control group(33.3%, 10/30), the difference was statistically significant. Conclusion Dezocine combined with dexmedetomidine in laparoscopic appendectomy after analgesic effect is significant, can effectively reduce the body pain and stress response, high safety, worthy of clinical active application promotion.
出处
《湖南师范大学学报（医学版）》
2018年第5期36-38,共3页
Journal of Hunan Normal University(Medical Sciences)
基金
四川省德阳市科技计划项目(2014SZ040)
