摘要
目的 :探究咖啡酸片在治疗宫颈癌化疗所致白细胞减少上的临床疗效。方法 :将2014年1月~2017年3月在本院接受化疗的104例宫颈癌患者作为研究对象,按入院先后分为观察组(51例)、对照组(53例)。两组患者行常规化疗方案进行治疗,化疗开始后24h皮下注射重组人粒细胞刺激因子进行预防性升白治疗,观察组患者则在上述基础上于化疗开始后口服咖啡酸片。对两组患者在化疗期间的白细胞计数变化以及化疗后骨髓抑制分级程度、继发感染情况以及在后续升白治疗中的白细胞恢复正常所用时间以及重组人粒细胞刺激因子用量进行分析比较。结果 :化疗前,两组患者的白细胞计数水平比较未见显著差异;化疗开始后,两组的白细胞计数水平显著下降,随后呈逐渐上升趋势,观察组在各阶段的白细胞计数水平均显著高于对照组,差异比较有统计学意义。化疗4周后,观察组的骨髓抑制程度分级情况明显优于对照组,差异有统计学意义。在化疗4周后的升白细胞治疗中,观察组在白细胞恢复正常所用时间以及重组人粒细胞刺激因子用量上均明显低于对照组。化疗期间,观察组的继发感染发生率为7.84%,明显低于对照组(22.64%),差异有统计学意义。结论 :化疗期间给予宫颈癌患者以咖啡酸片,能够显著缓解其白细胞减少的程度,有效地预防和控制了因化疗引起的骨髓抑制。
Objective To research the clinical effects of caffeic acid tablet in the treatment of chemotherapy-induced aleucocytosis in cervical cancer.Method From January 2014 to March 2017,104 cases of cervical cancer patients who received chemotherapy in our hospital were selected as the subjects.According to the order of admission,the patients were divided into the observation group(51 cases)and the control group(53 cases).Two groups of patients were treated with conventional chemotherapy,gave the Recombinant Human Granulocyte Colony-stimulating Factor by subcutaneous injection at the start of chemotherapy after 24 hours.The patients in the observation group received oral caffeic acid tablets on the basis of chemotherapy.Compared and analyzed the changes of WBC count in the two groups during chemotherapy,the grade of bone marrow suppression and secondary infection after chemotherapy,the time of normal leukocyte recovery and the amount of Recombinant Human Granulocyte Colony-stimulating Factor.Result Before chemotherapy,there was no significant difference in WBC count between the two groups.After the start of chemotherapy,the white blood cell count levels in the two groups significantly decreased,then increased gradually,the white blood cell count of the observation group in each stage were significantly higher than those in control group,the differences were statistically significant.After 4 weeks of chemotherapy,the grade of bone marrow suppression in the observation group was obviously better than that in the control group,the difference was statistically significant.After 4 weeks of chemotherapy,the time of normal leukocyte recovery and the amount of Recombinant Human Granulocyte Colony-stimulating Factor in the observation group were significantly lower than those in the control group.During chemotherapy,the incidence of secondary infection was 7.84%,which was significantly lower than that of the control group(22.64%),and the difference was statistically significant.Conclusion Give the patients of cervical cancer for the caffeic acid tablets during chemotherapy,can significantly reduce the extent of its decrease in leukocytes,effectively prevented and controlled myelosuppression due to chemotherapy.
作者
齐静
Qi Jing(Department of Obstetrics,Xining First People’s Hospital,Xining 810000,China)
出处
《湖南师范大学学报（医学版）》
2019年第3期92-96,共5页
Journal of Hunan Normal University(Medical Sciences)
关键词
咖啡酸片
宫颈癌
化疗
白细胞减少
骨髓抑制
caffeic acid tablets
cervical cancer
chemotherapy
aleucocytosis
myelosuppression
