摘要
目的:观察肿痛安胶囊联合甲硝唑片治疗慢性牙周炎的临床疗效。方法:将120例慢性牙周炎患者按照随机数字表法分为对照组A、对照组B和治疗组,每组各40例,同时选择30名健康受试者为健康对照组。所有患者均予以基础治疗,对照组A口服甲硝唑片,对照组B口服肿痛安胶囊,治疗组口服肿痛安胶囊联合甲硝唑片。比较三组患者的临床疗效,检测各组患者治疗前后牙周指标、血清和龈沟液炎性因子[白细胞介素-17(interleukin-17,IL-17)、白细胞介素-23(interleukin-23,IL-23)、白细胞介素-10(interleukin-10,IL-10)和转化生长因子-β(transforming growth factor-β,TGF-β)]。结果:对照组A与对照组B有效率比较,差异无统计学意义(P> 0. 05),治疗组有效率高于对照组A和对照组B,差异具有统计学意义(P <0. 05)。各组患者治疗后牙周指标均有改善,治疗组各项指标最接近健康对照组。各组患者治疗后血清及龈沟液IL-17和IL-23水平低于治疗前,差异具有统计学意义(P <0. 05),但对照组A和对照组B治疗后血清及龈沟液IL-17和IL-23水平仍显著高于健康对照组(P <0. 05),治疗组治疗后血清及龈沟液IL-17和IL-23水平与健康对照组比较,差异无统计学意义(P> 0. 05)。三组患者治疗前后血清及龈沟液IL-10和TGF-β水平比较,差异无统计学意义(P> 0. 05)。结论:肿痛安胶囊联合甲硝唑片治疗慢性牙周炎可改善患者临床症状。
Objective:To observe the clinical curative effect of Zhongtongan Capsules(ZTAC)on chronic periodontitis.Methods:A total of 120 patients with moderate to severe chronic periodontitis were divided into the control group A,the control group B and the treatment group according to random number table method,with 40 cases in each group.At the same time,30 healthy subjects were selected as the healthy control group.All the patients were given basic treatment.The control group A was additionally given Metronidazole Tablets.The control group B was additionally given ZTAC.The treatment group was additionally given ZTAC and Metronidazole Tablets together.The clinical effects of three groups were compared,and the periodontal indexes,serum and gingival crevicular fluid inflammatory factors,including interleukin-17(IL-17),interleukin-23(IL-23)interleukin-10(IL-10)and transforming growth factor-β(TGF-β)were measured before and after the treatment.Results:There was no significant difference in the effective rate between the control group A and the control group B(P>0.05).The effective rate of treatment group was higher than that of control group A and that of the control group B,and the difference was statistically significant(P<0.05).After the treatment,the periodontal indexes of each group were improved,and those of the treatment group were closest to those of the healthy control group.Compared with before the treatment,the levels of IL-17 and IL-23 in serum and gingival crevicular fluid of each group after the treatment were lower than those before the treatment,and all the differences were statistically significant(P<0.05).But the levels of IL-17 and IL-23 in serum and gingival crevicular fluid of the control group A and the control group B after the treatment were still significantly higher than those of the healthy control group(P<0.05).-There was no significant difference in the levels of 17 and IL-23 between the treatment group and the healthy control group(P>0.05).There was no significant difference in the levels of IL-10 and TGF-βin serum and gingival crevicular fluid between the three groups before and after the treatment(P>0.05).Conclusion:ZTAC can be used as an adjunct to the treatment of chronic periodontitis,which can improve the clinical symptoms of patients.
作者
朱天杰
钱文昊
ZHU Tian-jie;QIAN Wen-hao(Xuhui District Dental Disease Prevention and Control Institute of Shanghai,Shanghai,China,200032)
出处
《河南中医》
2019年第8期1234-1238,共5页
Henan Traditional Chinese Medicine
基金
2017年上海市徐汇区医学尖峰学科项目(SHXH201706)
