摘要
Objective To assess the effect of tetrandrine (Tet) pulmonary targeting microspheres on hypoxic pulmonary hypertension and evaluate its selective action on pulmonary circulation.Methods Twenty rats were exposed to hypoxic conditions for 3 weeks. Ten rats were used as normoxic controls. We administered Tet pulmonary targeting microspheres to 10 hypoxic rats and Tet aqueous solution to 10 hypoxic rats and the 10 control rats. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization, and mean systemic blood pressure (mSBP) was measured by left femoral catheterization. Results Rats exposed to hypoxia developed pulmonary hypertension. The decrease in mPAP in rats treated with Tet pulmonary targeting microspheres was significantly greater than that in rats receiving Tet aqueous solution (P【0.05), and the effects were longer with Tet pulmonary targeting microspheres. Moreover, Tet pulmonary targeting microspheres, unlike Tet aqueous solution, did not decrease mSBP.Conclusion Tet pulmonary targeting microspheres were more effective than Tet aqueous solution in treating hypoxic pulmonary hypertension and acted selectively on the pulmonary circulation.
目的 评价汉防己甲素 (Tet)肺靶向微球对低氧性肺动脉高压的治疗效应及其对肺循环的选择性作用。方法 2 0只大鼠经低氧处理 3周 ,另 10只大鼠作为正常对照。对 10只低氧大鼠给予Tet肺靶向微球 ,对 10只低氧大鼠和 10只正常大鼠给予Tet水溶剂。以右心导管法测定大鼠肺动脉平均压 (mPAP) ,经左股动脉插管测定体循环平均压 (mSBP)。结果 低氧后大鼠出现了肺动脉高压。大鼠应用Tet肺靶向微球后 ,其mPAP的降低较Tet水溶剂治疗组更为明显 (P <0 0 5 ) ,且作用持续时间明显延长 ;与Tet水溶剂不同 ,应用Tet微球后大鼠mSBP无显著变化。结论 Tet肺靶向微球对肺循环具有较好的选择性 ,可明显增强Tet降低mPAP的效应。
