摘要
目的探讨急性化脓性阑尾炎围术期左氧氟沙星不同用药方案对切口感染的预防效果。方法方便选取2016年3月—2018年7月收治的92例急性化脓性阑尾炎患者,以随机数字表法分为对照组46例和观察组46例,均行阑尾切除术治疗,抗感染药均采用左氧氟沙星。观察组用药方案为术前30 min静脉滴注0.4 g+术后静脉滴注0.2 g/次,2次/d;对照组用药方案为术前30 min静脉滴注0.4 g+术后静脉滴注0.4 g/次,1次/d。观察两组术前、术后3 d炎性因子水平变化,术后切口换药次数、切口愈合时间、住院时间以及术后切口感染情况。结果术前两组炎性因子水平差异无统计学意义(P>0.05),术后均有下降,观察组术后3 d血清IL-8、IL-6、CRP水平均较对照组低,差异有统计学意义(P<0.05);观察组术后切口换药次数、切口愈合时间及住院时间与对照组对比,差异有统计学意义((t=5.587、3.610、3.472,P<0.05);观察组术后切口感染发生率为2.17%,同对照组13.04%对比,差异有统计学意义(χ~2=3.989,P<0.05)。结论以术前30 min静脉滴注0.4 g+术后静脉滴注0.2 g/次,2次/d方案使用左氧氟沙星,可有效降低急性化脓性阑尾炎患者术后切口感染发生风险,也能促进患者康复,值得推广。
Objective To investigate the preventive effect of different administration regimens of levofloxacin in patients with acute suppurative appendicitis on wound infection.Methods 92 patients with acute suppurative appendicitis admitted from March 2016 to July 2018 were convenient selection randomly divided into the control group(46 cases)and the observation group(46 cases).All patients underwent appendectomy.The anti-infective drugs were levofloxacin.The observation group was given intravenous infusion of 0.4 g+for 30 min before operation,followed by intravenous infusion of 0.2 g/times,twice per day.The control group was given intravenously for 30 min before surgery for 0.4 g/time after intravenous infusion,1 time/d.The changes of inflammatory factors in the two groups before and after surgery were observed.The number of incision dressings,wound healing time,hospitalization time and postoperative wound infection were observed.Results There was no significant difference in the levels of inflammatory factors between the two groups(P>0.05).The levels of serum IL-8,IL-6 and CRP in the observation group were lower than those in the control group.Statistical significance(P<0.05);the number of incision dressing changes,incision healing time and hospitalization time in the observation group were significantly different from those in the control group(t=5.587,3.610,3.472,P<0.05);observation group of the incidence of postoperative incision infection was 2.17%,compared with 13.04%in the control group.The difference was statistically significant(χ~2=3.989,P<0.05).Conclusion Intravenous infusion of 0.4 g+before 30 min before surgery,intravenous infusion of 0.2 g/times,2 times/d,using levofloxacin,which can effectively reduce the risk of postoperative wound infection in patients with acute suppurative appendicitis,can also promote rehabilitation of patients,it is worth promoting.
作者
吕洪涛
孙红敏
LYU Hong-tao;SUN Hong-min(Department of Surgery,Handian Town Health Center,Zouping,Shandong Province,256209 China;Department of Gynecology,Gaoxin Community Health Service Center,Zouping,Shandong Province,256200 China)
出处
《中外医疗》
2019年第6期112-114,共3页
China & Foreign Medical Treatment
关键词
急性化脓性阑尾炎
围术期
左氧氟沙星
不同用药方案
切口感染
Acute suppurative appendicitis
Perioperative period
Levofloxacin
Different medication regimen
Wound infection
