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尿β_2—m、Alb、IgG对糖尿病肾病早期诊断的价值 被引量:2

Value of β_2-m、Alb and IgG in urine in early diagnosis of diabetic nephropathy
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摘要 [目的 ]探讨尿 β2 —m、Alb、IgG对糖尿病肾病早期诊断的价值。 [方法 ]采用放射免疫分析法检测 39例正常人及 72例糖尿病患者尿 β2 —m、Alb、IgG的质量浓度 ,并与血BUN、Cr等指标比较。[结果 ]糖尿病组尿 β2 —m、Alb、IgG的质量浓度量分别为 (332 .76± 98.4 2 )ng/mL、(2 7.37±10 .6 4)、(8.5 7± 3.0 4 ) μg/mL ,明显高于对照组 (P值分别为 <0 .0 0 1,<0 .0 0 1,<0 .0 1) ,其阳性率均高于常规评价肾功能的指标如BUN、Cr等 (与Cr比较 ,p值分别为 <0 .0 5 ,<0 .0 1,<0 .0 5 )。在尿Alb阴性者中 ,有 14例 β2 —m阳性。[结论 ]尿微量蛋白 β2 -m与Alb的联合检测有助于糖尿病肾病的早期诊断。 To explore the value of β 2-m?Alb and IgG of urine in the early diagnosis of diabetic nephropathy . The authors measured the urine level of β 2-m?Alb and IgG in 39 normal cases and 72 patients with DN, and compared them with BUN and Cr in serum. The β 2-m?Alb and IgG level of patients with DN are (332.76±98.42) ng/mL?(27.37±10.64) μg/mL and (8.57±3.04) μg/mL respectively, and higher than those in normal cases remarkably (the P value is <0.001,<0.001,<0.01 respectively) , the rate of patients whose urine level is positive are higher than BUN and Cr (the P value is <0.05,<0.01,<0.05 respectively). The β 2-m levels are higher abnormally in 14 patients whose Alb level is negative . [Conclusion] The detection of urine β 2-m?Alb and IgG are valuable in the early diagnosis of DN; the combined use of these three indexes can elevate the positive rate of DN diagnosis.
出处 《大连医科大学学报》 CAS 2002年第4期256-258,共3页 Journal of Dalian Medical University
关键词 糖尿病肾病 尿微量蛋白 放射免疫 diabetic nephropathy radioimmunoassay Alb β 2-m
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  • 1[1]Hiratsuka N, Shiba K, Nishide K, et al. Analysis of urinary albumin.transferrin, N - acetylbeta - D - glucosaminidase and beta 2 - microglobulin in patients with impaired glucose tolerance. J Clin Lab anal 1998; 12(6) :351
  • 2[2]Erasmus RT, Okesina B. Microalbuminuria in clinic population of type 2 Melanesian diabetics: relationship to glycemic control, blood presure and duration cf diabeties. Cent Afi J Med 1999;45(1):291
  • 3[3]Beetham R, Cattell WR. Proteinuria: pathophysiology, significance and recommendation for measurement in clinical practice. Ann Clin Biochem1993;30(5) :425
  • 4[4]Ziyadeh FN, Goidfarb S. The renal tubulointerstium in diabetes mellitus. Kidney Int 1991 ;39(3) :464
  • 5熊苏.中老年高血压病和糖尿病早期肾脏损害的检测[J]中华核医学杂志,2000(05).
  • 6何云南,肖祥熊.β_2-m RIA在泌尿系疾病中的应用[J].放射免疫学杂志,1993,6(3):187-191. 被引量:7
  • 7林素姐,代庆东,林文狮,张喜媛,赵秀钗.53例慢性贫血患者血、尿β_2-m、尿Alb变化分析[J].放射免疫学杂志,2001,14(3):161-161. 被引量:1

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