摘要
目的探讨妇科恶性肿瘤患者血栓前状态生物指标的变化。方法检测38例妇科恶性肿瘤患者手术前后及20例正常非孕妇女的血管性血友病因子(vWF)、血小板ɑ-颗粒膜蛋白(GMP-140)、抗凝血酶(AT-Ⅲ)、蛋白C依赖的活化部分凝血酶原时间(PCAT)、纤溶酶原(PLG)、纤溶酶原激活物抑制物(PAI)、D-二聚体和组织纤溶酶原激活物(t-PA)等指标。结果妇科恶性肿瘤患者术前vWF含量、GMP-140、AT-Ⅲ、PLG、PAI、D-二聚体均比对照组高(P<0.01),而术后升高更明显;PCAT手术前、后均明显低于正常非孕妇女;而组织纤溶酶原激活物(t-PA)则无显著性改变(P>0.05)。结论提示妇科恶性肿瘤患者术前血液呈血栓前状态,术后呈更明显的血栓前状态。
Objective To study the changes in the variables in patients with gynecological malignancies after operation. Methods Platelet alphagranule membrane protein (GMP-140), von Willebrand Factor (vWF), antithrombin Ⅲactivity (AT-Ⅲ), protein C-dependent partial thromboplastin activation time, plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI), D-Dimer were examined in 20 normal non-pregnant women and 38 patients after operation with gynecological malignancies. Results vWF, GMP-140, PLG, D-Dimer, and PAI of patients with malignancies before operation were obviously higher than those of the healthy women (P<0.01). After operation the parameters were obviously elevated in the patients (P<0.01). AT-Ⅲand partial thromboplastin activation time were significantly reduced in comparison with the healthy subjects (P<0.01). t-PA showed no significant difference between the groups (P>0.05). Conclusion Obvious prethrombotic state characterizes the patients with gynecological malignancies after operation.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第1期84-86,共3页
Journal of First Military Medical University
关键词
妇科恶性肿瘤
术后
血液
血栓前状态
检测
neoplasm, geynecological
prethrombotic state
deep venous thrombosis
