摘要
目的观察尿毒清片对大鼠腺嘌呤CRF模型的影响并与原剂型比较,为其临床应用和剂型改革提供实验依据。方法建立大鼠腺嘌呤CRF模型,给药(尿毒清片剂和颗粒剂)后,观察血尿素氮(BUN)和肌酐(Scr)、血液学及生化、肾组织学的变化。结果两种剂型均能降低血BUN、Scr,改善电解质水平,升高RBC、Hb、HCT,减轻肾组织的病理变化。结论尿毒清片剂与颗粒剂治疗肾衰大鼠同样有效。在改善贫血症状方面,尿毒清片剂优于颗粒剂。
Objective To compare the effects of Niaoduqing Tablet and Niaoduqing Granule in tre atingchronic renal failure(CRF)induced by adenine in rats,which is expected to provide some lab oratory data for the clinical applic ation and innovation of the dosage forms.Methods CRF rat models induced by adenine were administered with Niaoduqing Tabl et or Niaoduqing Granule and then the seru m levels of BUN and Scr,haematologic al and biochemical indexes and renal histolog-ical features were observed.Results Both of two forms reduced serum levels of BUN and Scr,ameliorate the electrolyte,increase the number of red blood cell,hemoglobin content and haematocrit and alleviate pathological changes of the kidney tissue.Conclusion Both Niaoduqing Tablet and Niaoduqi ng Granule is effective in treating CRF in rats and the effect of Niaoduqing Tablet in ameliorating a nemia is superior to that of Niaoduqi ng Granule.
出处
《中药新药与临床药理》
CAS
CSCD
2003年第1期17-20,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
尿毒清片
药理学
肾功能衰竭
中药疗法
病理生理学
Niaoduqing Tablet /pharmacology
Renal failure,chronic /TCD therapy
Renal failure,chronic /phys-iopathol
Renalfailure,chronic /pathology
Disease models,animal
