摘要
目的 探讨肿瘤特异性生长因子 (TSGF)在鼻咽癌诊断、疗效判断中的应用价值。方法 对 2 16例放射治疗前鼻咽癌患者及根治性放疗后的 73例患者行血清TSGF含量检测 ,并对其各临床分期行血清TSGF含量及阳性率比较。结果 鼻咽癌患者放疗前血清TSGF含量及阳性率明显升高 ,放射治疗结束后TSGF含量及阳性率均明显下降。鼻咽癌诊断的敏感性为 6 3 .89% ( 138/2 16 ) ,特异性为 95 .2 4% ( 4 0 /42 ) ,准确性为 6 8.99% ( 178/2 5 8)。行临床分期观察发现 :放疗前Ⅳa、Ⅳb期患者血清TSGF与Ⅰ、Ⅱ、Ⅲ期比较差异有显著性 (P <0 .0 5 ) ,TSGF阳性率比较 ,Ⅳb期患者血清TS GF与Ⅰ、Ⅱ、Ⅲ、Ⅳa期 ,Ⅳa期与Ⅰ、Ⅱ期差异有显著性 (P <0 .0 5 ) ,放疗后Ⅰ、Ⅱ、Ⅲ、Ⅳa期与放疗前血清TSGF含量比较差异无显著性 (P >0 .0 5 ) ,但阳性率比较差异均有显著性 (P <0 .0 5 )。结论 测定血清TSGF水平对鼻咽癌的诊断、疗效判断、病情监测和指导治疗有一定意义。
Objective To investigate the value of the Tumor Specific Growth Factor (TSGF) in the diagnosis of nasopharyngeal carcinoma (NPC).Methods The serum TSGF levels were measured in 42 healthy individuals and 216 NPC patients before radiotherapy and 73 NPC patients after radiotherapy. According to 1992 FuZhou staging system, 216 newly diagnosis patients were classified as 3 stageⅠ, 26 stage Ⅱ, 78 stage Ⅲ, 69 stage Ⅳa, 40 stage Ⅳb. 73 patients after radiotherapy were classified as 3 stage Ⅰ, 17 stage Ⅱ, 39 stage Ⅲ, 14 stage Ⅳa.Results The serum TSGF levels of patients received radiotherapy were higher than those of healthy individuals (P<0.05). The levels of serum TSGF decreased after radiotherapy (P<0.05). The sensitivity, specificity and accuracy were 63.89%, 95.24% and 68.99%, respectively.Conclusions The determination of serum TSGF is helpful to the diagnosis, estimating the clinical outcome, monitoring the disease and directing the treatment of NPC.
出处
《右江民族医学院学报》
2003年第1期20-22,共3页
Journal of Youjiang Medical University for Nationalities
关键词
血清
肿瘤特异性生长因子
测定
鼻咽癌
诊断
nasopharyngeal neoplasms
growth substances
diagnosis, laboratory
