摘要
目的研究术前乳腺癌患者C-erbB-2蛋白的表达及其临床意义。方法术前对30例乳腺癌患者行细针抽吸(FNA)涂片,用免疫细胞化学(ICA)检测C-erbB-2蛋白的表达,同时组化检测相应术后组织切片上的C-erbB-2蛋白方法。结果C-erbB-2在细针抽吸涂片蛋白的阳性率为53.3%(16/30),在组织切片上为43.3%(13/30)。两者无显著性差异(P>0.05)。C-erbB-2蛋白在细针抽吸涂片的表达情况与临床分期呈正相关(P<0.05)。有腋窝淋巴结转移者C-erbB-2蛋白阳性表达率显著高于无腋窝淋巴结转移者。结论细针抽吸涂片检测C-erbB-2蛋白可帮助术前判断乳腺癌的预后并指导治疗。
Objective To study the expression of C -erbB -2protein in breast carcinoma in preoperation patients and its clinical significance.Methods Preoperative fine-needle aspiration (FNA)smears were undergone on30cases with breast carcinoma and the expression of C-erbB-2protein was determined by immunocytochemical assay(ICA)and histological sections of relevant case by immunohisto-chemistry.Results C-erbB-2protein positive expression rate was53.3%(16/30)on FNA smears by ICA and43.3%(13/30)on the corresponding histological section by immunohistochemistry.The two methods had no significant difference(P>0.05).There was significant positive relationship between C-erbB-2protein expression on FNA smears and clinical TNM stages (P<0.05).C-erbB-2positive expression rate in axillary lymph node metastases was higher than in no axillary lymph node metastases.Conclusion Preoperative FNA is beneficial to estimate theprognosis and to guide treatment in breast cancer patients.
出处
《实用医药杂志》
2003年第1期19-20,共2页
Practical Journal of Medicine & Pharmacy
