摘要
本文首次报道用催化动力学和库仑分析相结合的方法测定抗癌药物乐疾宁中的主要成份6-巯基嘌呤(6-MP)。此法基于测定与催化剂(或称诱导剂)6-MP浓度成正比的库仑池反应诱导期(从接通电源到指示电流突然增大到指定值的毫库仑数),从而求出催化剂6-MP的量。本法具有库仑分析法与催化动力学分析法的优点即准确、灵敏、快迅和简便。方法线性范围为1.47×10^(-7)～5.29×10^(-6)mol/L。应用于药物乐疾宁中6-MP的测定,回收率为95%～103%,结果满意。
A coulometric technique for the determination of 6-Mercaptopurine (6-MP) in antiumor drugshas been studied. It is based on induced reaction of anodically generated iodine with sodiumazide. The linear dependence of Q/Q_0 on the concentration of above mentioned inductor (6-MP)has been found. The determinations have been carried out in the range of 25～900×10^(-6)(i. e.1.47×10^(-7)～5.29×10^(-6)mol/L) of 6-MP with a good precision and the relation coefficient r is0.998. Most of the cations and anions do not interfere, but Pd^(2+), Pt^(4+), Au^(3+), Tl^+ and somedivalent sulphur compounds (such as S^(2-), S_2O_3^(2-), SO_3^(2-), SCN^-) interfere.
关键词
催化动力学
库仑滴定
6-巯基嘌呤
Catalytickinetic analysis
Coulometric analysis
6-Mercaptopurine (6-MP)
