摘要
目的 探讨 P5 3蛋白和表皮生长因子受体 ( EGFR)在胸腺上皮性肿瘤中表达的特征、相关性及其与肿瘤病理学分型的关系。方法 采用免疫组化方法观察 P5 3、表皮生长因子受体在 42例胸腺瘤的表达情况 ,同时检测雌激素受体 ( ER)、孕激素受体 ( PR)在正常胸腺和胸腺癌的表达。结果 1P5 3的表达随着肿瘤恶性程度的增高而增加 ( P<0 .0 5 ) ;良性胸腺瘤 :4.5 % ,恶性胸腺瘤 型 :3 3 .3 % ,恶性胸腺瘤 型 :10 0 %。 2 EGFR在浸润性胸腺瘤的表达明显高于良性非浸润性胸腺瘤 ( P<0 .0 5 ) ;良性非浸润性胸腺瘤 :2 2 .7% ,浸润性胸腺瘤 :5 5 .0 %。 3 ER、PR在正常胸腺和胸腺癌中无表达。结论 P5 3和 EGFR在胸腺瘤的表达可作为鉴别良。
Objective To explore the patterns, relativity of P53 protein and epidermal growth factor receptor (EGFR) expression in thymic epithelial tumors and their correlation with tumor pathological classification. Methods By using immunohistochemical assay, the expression of P53 protein and EGFR was detected in 42 cases of thymic epithelial tumors (22 cases of non-invasive thymomas, 15 invasive thymomas and 5 thymic carcinomas) Simultaneously, the expression of ER, PR in normal thymic tissues and thymic carcinomas was also detected. Results The expression of P53 protein was increased with the progression of thymic epithelial tumors (P<0.05): non-invasive thymoma, 4.5 %; malignant thymoma (categoryⅠ): 33.3 %; malignant thymoma (category Ⅱ): 100 %. The positive rate of EGFR expression in the invasive thymic tumors was higher than in non-invasive tumors (P<0.05): benign thymoma, 22.7 %; malignant thymoma: 55.0 %. No expression of ER and PR was detectable in normal thymic tissues and thymic carcinomas. Conclusion P53 protein and EGFR may play a role in thymoma progression. Detection of P53 and EGFR expression can help distinguish invasive from non-invasive tumors.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2003年第1期65-67,T001,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
