摘要
目的 :观察大剂量醛氢叶酸 (Leucovorin ,LV)加 5 氟尿嘧啶 (5 Fluorouracil,5 Fu)持续 4 8小时滴注联合顺铂(Cisplantin ,DDP)治疗晚期食管、贲门癌患者的疗效及其不良反应。方法 :病理确诊的食管、贲门癌 38例 ,食管鳞癌 2 4例 ,贲门腺癌 14例。采用DDP 2 5mg/m2 静脉滴注 30分钟 ,d1～ 3天 ,LV 2 0 0mg/m2 静脉滴注 2小时 ,5 Fu 0 5静脉推注 10分钟 ,然后 5 Fu 3 0 /m2 ,用输液泵连续输注 4 8小时 ,每 2 1天重复 ,2个周期以上评定疗效。结果 :完全缓解 (CR) 2例 (5 2 6 % ) ,部分缓解 (PR) 17例 (44 74 % ) ,稳定 (NC) 18例 (47 37% ) ,进展 (PD) 1例 (2 6 3% ) ,总有效率 5 0 % ,食管癌有效率 5 4 17% ,贲门癌有效率4 2 86 %。恶心、呕吐、口腔粘膜炎、骨髓抑制、腹泻及脱发为主要不良反应。结论 :大剂量LV +5 Fu 4 8小时滴注联合顺铂治疗晚期食管、贲门癌疗效较好 ,不良反应较小 。
Objective:To evaluate the efficacy an d toxicity of high dose leucovorin plus 5 Fu bolus and continuous infusion 48h combined with DDP in the patients with advanced cardioesophageal cancer.Methods:Thirty eight patients with a histologic diagnosi s of advanced cardioesophageal cancer, including twenty four patients with eso phageal cancer and fourteen patients with cardial cancer, were treated with DDP 25 mg/m 2 infusion 30 minutes d1-3, LV 200mg/m 2 infusion 2 hour, follo wed by 10 minute intravenous bolus of 5 Fu 500mg, then 48 hour infusion of 5 Fu 3 0/m 2 using an ambulatory pump, the patients were repeatedly treated every 21 days.Results:There were two CR, seventeen CR, eighteen NC an d one PD in this series with total response rate of 50%, the patients with esop hageal cancer obtained response rate 54 1%, the patients with cardial cancer o btained response rate 42 86%. The main side effects include nausea and vomitin g, mucositis, bone marrow suppression, alopecia, and diarrhea, toxicity was comparatively mild.Conclusion:High dose leucovorin plus 5 Fu bolus and co ntinuous infusion 48 hours combined with DDP had moderate activity but comparati vely mild toxicity for advanced cardioesophageal cancer.
出处
《临床肿瘤学杂志》
CAS
2003年第1期23-25,共3页
Chinese Clinical Oncology
关键词
醛氢叶酸
5-氟尿嘧啶
顺铂
食管癌
贲门癌
化学疗法
Leucovorin
5 Fluorouracil
Cispla tin
Esophageal cancer
Cardial cancer
Chemotherapy
