摘要
目的 :探讨 P16、C- myc及增殖细胞核抗原 ( PCNA)在脑胶质瘤发生发展过程中的作用。方法 :应用SABC免疫组化技术 ,检测胶质瘤 5 2例手术标本中 P16、C- myc及 PCNA表达与胶质瘤病理关系。结果 :P16阳性表达在不同级别肿瘤之间无显著差异 ( P>0 .0 5 ) ,复发组表达高于未复发组 ( P<0 .0 1) ; 、 级的 C- m yc得分显著高于 级得分 , 、 级、复发组的 PCNA指数分别高于 级、未复发组。结论 :P16及 PCNA表达与胶质瘤复发有关 ,C- myc及
Objective:To study the potential roles of P16?C-myc and proliferating cell nuclear antigen(PCNA) in the genesis and progression of glioma.Methods: Using immunohistochemical staining technique,52 cases of glioma specimens were examined for expressions of P16?C-myc and PCNA protein. The relationship between the immunoreactivity of P16?C-myc and PCNA and clinicopathology in glioma were analysed.Results:The expressions of P16 were not significantly different(P>0.05), recurrent group were higher than non-recurrent group(P<0.01). The C-myc scores and PCNA index of Ⅲ?Ⅳ were higher than those ofⅡ.Conclusion:The expressions of P16 and PCNA correlate with the recurrence of glioma; the expressions of C-myc and PCNA correlate with the grading of glioma.
出处
《南通医学院学报》
2003年第1期22-23,26,共3页
ACTA Academiae Medicinae Nantong
