摘要
目的 通过比较 5周岁儿童加强乙肝免疫对乙肝疫苗初免人群抗 HBs水平和HBsAg携带率的影响 ,评价 5周岁儿童乙肝疫苗加强免疫的效果。方法 采用ELISA检测HBsAg、抗 -HBc,RIA定量检测抗 -HBs ,比较观察 5周岁儿童乙肝疫苗加强免疫组和未加强免疫组乙肝免疫水平。结果 初免 5周岁儿童普遍进行加强免疫 ,可使人群抗体水平短时间 (3年 )明显提高 ,使抗 -HBs阳性率及滴度水平持续时间延长 ,但人群乙肝病毒感染率在 6年观察期内与未加强免疫组无明显差异。结论 提示在基础免疫
Objective To assess the effect of strengthening immunization for hepatitis B in 5 year old children by comparing the anti HBs and the rate of HBsAg carrier in the children performed strengthening immunization to those in the children performed only the first immunization. Methods The immunization levels of hepatitis B between the group of strengthening immunization and the control group were observed by detecting HBsAg and anti HBc with ELISA and anti HBs with RIA. Results Strengthening immunization in 5 year old children helped to significantly improve the antibody level of the population in short time(three years) and lengthen the lasting time for the positive rate of anti HBs and its titer. However, there was no significantly difference on the infective rates of hepatitis B between strengthening group and the control group in the 6 year period. Conclusions It could be concluded that strengthening immunization of hepatitis B vaccine five years after the basic immunization can not reduce the infective rate of the population.
出处
《浙江预防医学》
2003年第2期6-8,共3页
Zhejiang Journal of Preventive Medicine
关键词
儿童
乙肝疫苗
加强免疫
效果观察
Children Hepatitis B Vaccine Strengthening Immunization
