摘要
目的 研究磷酸川芎嗪丙烯酸树脂水分散体包衣缓释小丸的体外释药。方法 采用丙烯酸树脂RS3 0D和丙烯酸树脂RL3 0D混合液包衣制备磷酸川芎嗪缓释小丸 ,并考察包衣混合液中两种丙烯酸树脂水分散体比例、包衣增重、溶出介质pH对磷酸川芎嗪包衣制剂体外释药的影响。结果 随着包衣液中丙烯酸树脂RL3 0D/丙烯酸树脂RS3 0D比例增大、包衣增重降低、溶出介质pH增大 ,释药速率加快。结论 包衣液中丙烯酸树脂RL3 0D/丙烯酸树脂RS3 0D比例、包衣增重。
OBJECTIVE To study the dissolution profile of phosphate tetramethylpyrazine sustained release pellets coated with Eudragit pseudolatex. METHOD The Phosphate Tetramethylpyrazine sustained release pellets were coated with the mixture of Eudragit RL30D and Eudragit RS30D. The effects of the Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium on the drug releasing rate from the pellets were observed.RESULTS With the increasing of Eudragit RL30D/Eudragit RS30D ratio?decreasing of coating level or increasing of the pH value of disslution medium, the drug release from the pellets was increased.CONCLUSION The ratio of Eudragit RL30D/Eudragit RS30D ratio?coating level or different pH value of the dissolution medium significantly influenced phosphate tetramethylpyrazine release from sustained pellets.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2003年第1期28-30,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
磷酸川芎嗪
丙烯酸树脂水分散体
缓释
phosphate tetramethylpyrazine, eudragit pseudolatex, sustained release
