摘要
目的 :研究动脉粥样硬化性脑血栓形成病人血浆及脑脊液组织型纤溶酶原激活物 (t -PA )及其抑制物 (PAI -1)含量的变化及其临床意义。方法 :采用双抗体夹心固相酶联免疫吸附法(ELISA )检测 3 5例脑血栓形成病人血浆和其中 3 1例病人脑脊液t -PA及PAI -1抗原含量 ,与 3 5例正常对照组血浆和其中2 0例对照组脑脊液进行比较。结果 :脑血栓形成组血浆t -PA含量高于对照组 ,PAI -1含量显著高于对照组 ;其脑脊液t -PA、PAI -1含量均显著高于对照组 ;脑脊液中t -PA、PAI -1的含量分别与血浆中t -PA、PAI -1的含量呈正相关 ;脑血栓形成组病人神经功能缺损评分与血浆及脑脊液t -PA、PAI -1抗原含量呈正相关。结论 :脑血栓形成病人纤溶活性明显下降 ,t -PA及PAI -1参与了脑血栓形成之病理过程 ;t -PA及PAI -1抗原含量是反映体内纤溶活性的两个重要指标 ;可用血浆或脑脊液t-PA、PAI -1的含量作为判断病情的参考指标之一。
Objective:To observe the concentrations and clinical significance of tissue plasminogen activator(t-PA) antigen and plasminogen activator inhibitor-1 (PAI-1) antigen in plasma and cerebrospinal fluid from patients with acute cerebral thrombosis respectively.Methods:Plasma concentrations of t-PA and PAI-1 antigen were determined in 35 patients with acute cerebral thrombosis and in 35 normal control subjects,cerebrospinal fluid concentrations of t-PA and PAI-1 antigen were also determined in 31 patients with acute cerebral thrombosis and in 20 normal control subjects.Results:In acute cerebral thrombotic group,the plasma concentrations of t-PA antigen in patients were higher than those of control subjects(P<0.05);the Plasma concentrations of PAI-1 antigen were significantly higher(P<0.01).The cerebrospinal fluid concentrations of t-PA and PAI-1 antigen in the patients with acute cerebral thrombosis were significantly higher than those of control subjects;They were positively correlated with plasma concentrations of t-PA and PAI-1 antigen.The neurological defect scores in patients with acute cerebral thrombosis were positively correlated with plasma and cerebrospinal fluid concentrations of t-PA and PAI-1 antigen.Conclusion:The fibrinolytic activity in the patients with acute cerebral thrombosis was significantly lower than normal.It suggest that the plasma t-PA and PAI-1 might play a role in the pathogenetic of cerebral thrombosis.T-PA and PAI-1 may be two important indexes of reflecting fibrinolytic activity.
出处
《中西医结合心脑血管病杂志》
2003年第2期71-73,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
