摘要
目的 研究建立重离子束1 2 C6 + 照射人离体血诱发淋巴细胞微核的剂量 效应曲线。方法 用地面加速器产生的重离子1 2 C6 + (平均LET为 36 70keV μm) ,不同吸收剂量、不同吸收剂量率照射离体人血 ,用CB微核法观察双核淋巴细胞中的微核。结果 在 0～ 6Gy吸收剂量范围内 ,淋巴细胞微核率随吸收剂量的增加而增加 ,拟合的最佳方程为Y =6 6 5 0 9×D0 .85。结论 1 2 C6 + 照射人离体血诱发淋巴细胞微核在 0～ 6Gy吸收剂量范围内呈幂函数关系。
Objective\ To establish the dose\|effect curve of micronuclei for human peripheral blood lymphocytes after irradiation with heavy ion beams 12 C 6+ . Methods\ Heparinized whole blood samples were irradiated with heavy ion beams 12 C 6+ ,having 2 different dose\|rate values (dose\|rate=1 Gy/min and 3 Gy/min,mean LET=36 70 keV/μm),accelerated by a Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics,Chinese Academy of Sciences.Micronuclei in binuclear lymphocytes (CB method) were scored. Results\ At the absorbed dose range of 0\|6 Gy,the CB micronucleus frequency increased with the increase of absorbed dose.The best\|fitted equation is Y=665 09×D 0.85 . Conclusion\ At the absorbed dose range of 0\|6 Gy,the relationship between absorbed dose and micronucleus frequency of human peripheral blood lymphocytes induced by heavy ion beams 12 C 6+ is exponential.\;
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2003年第1期20-22,共3页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金资助项目 (10 10 5 0 12 )
