摘要
目的:探讨胰岛素治疗妊娠期糖尿病疗效及对血清胆固醇(TC)、总胆红素(TBil)、妊娠结局的影响。方法:收集2013年3月—2017年3月本院收治的妊娠期糖尿病患者90例,按随机数字表法分为对照组与观察组各45例。对照组给予常规控制饮食和运动治疗,观察组在对照组治疗基础上给予胰岛素治疗。比较两组治疗后剖宫产、空腹血糖控制满意率、血清胆固醇(TC)、总胆红素(TBil)水平及新生儿不良结局。结果:治疗后,观察组剖宫产率低于对照组,空腹血糖控制满意率高于对照组(P<0.05),血清中TC及TBil水平(2.17±0.24mmol/L)(13.68±1.73μmol/L)与对照组(3.46±0.38mmol/L)(10.30±1.12μmol/L)存在差异,新生儿出现低血糖、巨大儿及呼吸窘迫率高于对照组(P<0.05)。结论:胰岛素可降低妊娠期糖尿病患者剖宫产率,增强对血糖的调控作用,同时减轻了患者肾脏损害,改善妊娠结局,具有较好的临床疗效。
Objective:To investigate the effect of insulin for treating pregnant women with gestational diabetes mellitus(GDM),and to study influence of insulin on levels of serum cholesterol(TC),total bilirubin(TBil),and their pregnancy outcomes of women with GDM.Methods:90 women with GDM were selected and divided into control group and observation group according to the random digital table method from March 2013 to March 2017(45 cases in each group).The women in control group were given conventional treatment,while the women in observation group were given insulin except to conventional treatment.The incidences of preeclampsia and cesarean section,satisfactory rate of fasting blood glucose control(SRFBGC),levels of TC and TBil,and neonatal adverse outcomes were compared between the two groups.Results:The rate of cesarean section of women in observation group was significant lower than that of women in control group,while the SRFBGC was significant higher than that of women in control group(P<0.05).The serum level of TC[(3.5±0.4)mmol/L]of women in control group was significant higher than that[(2.2±0.2)mmol/L]of women in observation group,but the serum level of TBil[(10.3±1.1)μmol/L]was significant lower than that[(13.7±1.7)μmol/L]of women in observation group(P<0.05).The incidences of neonatal hypoglycemia,macrosomia,and respiratory distress in observation group were significant lower than those in control group(P<0.05).Conclusion:Insulin can reduce the rate of caesarean section of women with GDM,enhance the regulation of blood sugar,reduce renal damage,and improve the pregnancy outcomes.
作者
刘伟
万佳义
张继东
LIU Wei;WAN Jiayi;ZHANG Jidong(Shunyi District Hospital of Beijing,Beijing,101300)
出处
《中国计划生育学杂志》
2019年第3期346-348,共3页
Chinese Journal of Family Planning
